143 -10 (84) 2025 - Botirov D.A., Eshbaev E.A. - AGE-RELATED IMMUNOHISTOCHEMICAL CHARACTERISTICS OF DESMIN EXPRESSION IN MYOCARDIUM IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE

AGE-RELATED IMMUNOHISTOCHEMICAL CHARACTERISTICS OF DESMIN EXPRESSION IN MYOCARDIUM IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE

Botirov D.A. - Samarkand State Medical University

Eshbaev E.A. - Tashkent State Medical University

Shukurova Y.U. - Alfraganus University

Resume

Immunohistochemical studies of myocardium in patients with chronic ischemic heart disease were performed primarily using the following markers: desmin. The desmin marker used in this study is a protein structure found predominantly in the intermediate filaments of myocytes that form the myocardium. It serves as a scaffold factor that determines muscle contractility and is found in the sclera and cardiac muscle. This intermediate filament protein is expressed predominantly in the cytoplasm of cardiomyocytes, acquiring a rich golden-yellow color, along with uniform expression of components of healthy muscle tissue. It is characterized by homogeneous yellow staining of the cytoplasm.

Keywords: immunohistochemistry, morphology, chronic ischemic heart disease.

First page

815

Last page

820

For citation:Botirov D.A., Eshbaev E.A., Shukurova Y.U. - AGE-RELATED IMMUNOHISTOCHEMICAL CHARACTERISTICS OF DESMIN EXPRESSION IN MYOCARDIUM IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE//New Day in Medicine 10(84)2025 815-820 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

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