147 -10 (84) 2025 - Mamatova I.Y., Mamajonov Z.A. - ASSESSMENT OF THE ACUTE TOXICITY OF AsZafIr AND Asmair COMPOUNDS

ASSESSMENT OF THE ACUTE TOXICITY OF AsZafIr AND Asmair COMPOUNDS

Mamatova I.Y. - Andijan State Medical Institute

Mamajonov Z.A. - Andijan State Medical Institute

Ulugbekova G.J. - Andijan State Medical Institute

Resume

In this study, the acute toxicity of the synthesized compounds Complex-1 and Complex-2 was evaluated according to OECD-420 guidelines. The experiments were conducted via oral administration at a dose of 5000 mg/kg, and no mortality was observed during the 14-day observation period. The results indicated an LD₅₀ value > 5000 mg/kg, confirming the low toxicity and biological safety of the compounds.

Keywords: AsZafIr, Asmair, LD₅₀, OECD-420, acute toxicity, biological safety.

First page

836

Last page

838

For citation:Mamatova I.Y., Mamajonov Z.A., Ulugbekova G.J. - ASSESSMENT OF THE ACUTE TOXICITY OF AsZafIr AND Asmair COMPOUNDS//New Day in Medicine 10(84)2025 836-838 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

List of References

  1. OECD (2001) Guideline for testing of chemicals. Acute Oral Toxicity – Fixed Dose Procedure No 420 Руководящий документ ОЭСР Test № 420 «Acute Oral Toxicity - Fixed Dose Procedure». Section 4, OECD Publishing, Paris, https://doi.org/10.1787/9789264070943-enga
  2. Руководство по проведению доклинических исследований лекарственных средств. Часть первая / Под ред. А.Н. Миронова. М.: Гриф и К, 2012; 944 cтр.
  3. Доклиническое исследование лекарственных средств (методические рекомендации). Киев. - 2002, с.587 //под ред. А.В. Стефанова.

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