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  • 11 -11 (85) 2025 - Qudratov F.O., Bafoyeva Z.B. - DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN GUILLAIN–BARRÉ SYNDROME

11 -11 (85) 2025 - Qudratov F.O., Bafoyeva Z.B. - DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN GUILLAIN–BARRÉ SYNDROME

DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN GUILLAIN–BARRÉ SYNDROME

Qudratov F.O. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Bafoyeva Z.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Guillain–Barré syndrome (GBS) is an acute autoimmune disorder of the peripheral nervous system characterized by rapidly progressing weakness and paralysis. Early diagnosis and outcome prediction remain challenging due to the clinical heterogeneity and fast disease progression. In recent years, biomarkers reflecting immune pathogenesis, axonal damage, and inflammation have been actively investigated. Among them, antiganglioside antibodies (GM1, GD1a, GQ1b), inflammatory cytokines (IL-6, TNF-α, IL-17), and neurofilament light chain (NfL) have shown particular promise. Their detection in serum or cerebrospinal fluid can improve disease stratification, prognosis, and treatment monitoring. This review summarizes current data on the diagnostic and prognostic value of biomarkers in GBS, highlighting their potential role in personalized medicine.

Keywords: Guillain–Barré syndrome, biomarkers, antiganglioside antibodies, cytokines, neurofilaments, prognosis

First page

60

Last page

62

For citation:Qudratov F.O., Bafoyeva Z.B. - DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN GUILLAIN–BARRÉ SYNDROME//New Day in Medicine 11(85)2025 60-62 https://newdayworldmedicine.com/en/new_day_medicine/11-85-2025

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