45 -2 (40) 2022 — Raxmatullaeva Sh.B., Muminova M.T. — INTESTINAL MICROBIOCENOSIS IN CHILDREN WITH ACUTE INFECTIOUS DIARRHEA DEPENDING ON THE DEGREE OF IMMUNODEFICIENCY IN HIV INFECTION

INTESTINAL MICROBIOCENOSIS IN CHILDREN WITH ACUTE INFECTIOUS DIARRHEA DEPENDING ON THE DEGREE OF IMMUNODEFICIENCY IN HIV INFECTION

Raxmatullaeva Sh.B., Tashkent Medical Academy

Muminova M.T. Tashkent Medical Academy

Resume

499 HIV-infected children aged 0-18 were examined: the main group consisted of 261 children with acute infectious diarrhea, the control group consisted of 238 children without diarrhea. The diagnosis was made on the basis of clinical, virological, immunological, bacteriological, serological and statistical data.

In children with acute infectious diarrhea, profound disorders of the intestinal microbiocenosis were significantly more often recorded with moderate and high degrees of immunodeficiency in HIV infection compared with low and severe degrees of immunodeficiency (P<0.05). Violation of the obligate and facultative intestinal microflora in the compared groups is significantly more often observed with a high and severe degree of immunodeficiency. According to the detection of pathogenic bacteria Salmonella and Shigella between the compared groups, depending on the degree of immunofecitis in HIV infection in the compared groups, there are significant differences (P<0.05), with the detection of Cambilobacter and Yersinia, no significant differences were found.

Key words: HIV infection, children, immunodeficiency, CD4+ cells, acute infectious diarrhea, obligate, facultative, pathogenic intestinal microflora.

First page

233

Last page

237

For citation: Raxmatullaeva Sh.B., Muminova M.T. INTESTINAL MICROBIOCENOSIS IN CHILDREN WITH ACUTE INFECTIOUS DIARRHEA DEPENDING ON THE DEGREE OF IMMUNODEFICIENCY IN HIV INFECTION //New Day in Medicine 2(40)2022 233-237 https://cutt.ly/CATXk0j

LIST OF REFERENCES:

1. Ashurova R. SH. Бактериальные и грибковые оппортунистические инфекции у ВИЧ-позитивных детей / Р. Ш. Ашурова, Н. М. Ходжаева, Н. С. Джураева, А.М.Салимов // Вестн. Академии медицинских наук Таджикистана.
2. Kolpakova N.V. Клинико-анамнестические и иммунологические показатели у ВИЧ-инфицированных больных с астроэнтерологической патологией / Н.В. Колпакова, А.А. Курмангулов, А.А. Мельников, Н.А. Уварова, Ю.А. Петрова // ВИЧ-инфекция и иммуносупрессии. – 2018. – № 1 (10). – С. 78–83.
3. Nigmatova L.M. Влияние уровня CD 4 – лимфоцитов на течение ВИЧ-инфекции / Л.М. Нигматова, А.А. Бийкузиева // Авиценна. – 2017. – № 7. – С. 36–39.
4. Back-Brito G.N. Staphylococcus spp., Enterobacteriaceae and Pseudomonadaceae oral isolates from Brazilian HIV-positive patients. Correlation with CD4 cell counts and viral load / G. N. Back-Brito, V. N. R. Ackhar, S.M. R. Querido, S.S. F. Santos, A.O. Jorge, S. Reis Ade, C.Y. Koga-Ito // Arch. Oral Viology. – 2011. – Vol. 56 (10). – P. 1041−1046.
5. Dillon S.M. The gut microbiome and HIV- pathogenesis: a two-way street / S.M. Dillon, D. N. Frank, C. C. Wilson // AIDS. – 2016. – Vol. 30. – P. 2737−2751.
6. Monaco C.L. Altered virome and bacterial microbiome in Human immunodeficiency virus-associated acquired immunodeficiency syndrome / C. L.Monaco, D. B. Gootenberg, G. Zhao, S. A. Handley, M. S. Ghebremichael, E.  S. Lim, A. Lankowski, M. T. Baldridge, C. B. Wilen, M. Flagg, J. M. Norman, B. C. Keller, J. M. Luévano, D. Wang, Y. Boum, J. N. Martin, P. W. Hunt, D. R. Bangsberg, M. J. Siedner, D. S. Kwon, H. W. Virgin // Cell Host and Microbe. – 2016. – Vol. 19. – P. 311−322.
7. Serrano-Villar S. Gut bacteria metabolism impacts immune recovery in HIVinfectedindividuals / S. Serrano-Villar, D. Rojo, M. Martínez-Martínez, S. Deusch, J. F.Vázquez-Castellanos, R. Bargiela, T. Sainz, M. Vera, S. Moreno, V. Estrada, M. J.Gosalbes, A.Latorre, J. Seifert, C. Barbas, A. Moya, M. Ferrer // EBioMedcine. – 2016.– Vol. 8. – P. 203–216.