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  • 45 -11 (85) 2025 - Khomidov F.K., Aktamov A.F. - COGNITIVE AND SOMATIC FEATURES OF CHILDREN WITH CHRONIC KIDNEY DISEASE: UNDERRECOGNIZED ASPECTS OF EARLY SCREENING

45 -11 (85) 2025 - Khomidov F.K., Aktamov A.F. - COGNITIVE AND SOMATIC FEATURES OF CHILDREN WITH CHRONIC KIDNEY DISEASE: UNDERRECOGNIZED ASPECTS OF EARLY SCREENING

COGNITIVE AND SOMATIC FEATURES OF CHILDREN WITH CHRONIC KIDNEY DISEASE: UNDERRECOGNIZED ASPECTS OF EARLY SCREENING

Khomidov F.K. - Children's National Medical Center

Aktamov A.F. - Termez Branch of Tashkent State Medical University

Naimova Sh.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This study assessed the prevalence and diagnostic significance of non-specific signs—fatigue, attention deficits, sleep disturbances, anemia, and growth retardation—in 150 children with stages I–III chronic kidney disease (CKD). These symptoms were present in the majority of patients and significantly differed from the control group. Correlations were established between decreased eGFR and the severity of cognitive and somatic impairments. The combination of fatigue, anemia, and poor academic performance showed high diagnostic value (AUC=0.94) for CKD detection. It is recommended to include these signs in pediatric screening programs for early identification of CKD.

Keywords: chronic kidney disease; children; cognitive impairment; fatigue; growth; anemia; early screening.

First page

250

Last page

262

For citation:Khomidov F.K., Aktamov A.F., Naimova Sh.A - COGNITIVE AND SOMATIC FEATURES OF CHILDREN WITH CHRONIC KIDNEY DISEASE: UNDERRECOGNIZED ASPECTS OF EARLY SCREENING//New Day in Medicine 11(85)2025 250-262 https://newdayworldmedicine.com/en/new_day_medicine/11-85-2025

List of References

  1. Hooper SR, Gerson AC, Butler RW, et al. Neurocognitive functioning of children and adolescents with mild-to-moderate chronic kidney disease. // Clin J Am Soc Nephrol. 2011;6(8):1824-1830.
  2. Johnson RJ, Harshman LA. Neurocognition in pediatric chronic kidney disease: a review of data from the CKiD study. // Semin Nephrol. 2021;41(5):446-454.
  3. Mendley SR, Matheson MB, Shinnar S, et al. Duration of chronic kidney disease reduces attention and executive function in pediatric patients. // Kidney Int. 2015;87(4):800-806.
  4. Duquette PJ, Gipson DS, Hooper SR, et al. Differential attention functioning in pediatric chronic kidney disease. Front Hum Neurosci. // 2022;16:897131.
  5. Lande MB, et al. Casual blood pressure and neurocognitive function in children with CKD: a report of the CKiD study. // Clin J Am Soc Nephrol. 2011;6(8):1831-1837.
  6. Sinha R, Davis ID, Matsuda-Abedini M. Sleep disturbances in children and adolescents with non-dialysis-dependent CKD. // Arch Pediatr Adolesc Med. 2009;163(9):850-855.
  7. Roumelioti ME, Wentz A, Schneider MF, et al. Sleep and fatigue symptoms in children and adolescents with CKD: a cross-sectional analysis from the CKiD study. // Am J Kidney Dis. 2010;55(2):269-280.
  8. Stabouli S, Papadimitriou E, Printza N, Dotis J, Papachristou F. Sleep disorders in pediatric chronic kidney disease patients. // Pediatr Nephrol. 2016;31(8):1221-1229.
  9. Haffner D. Strategies for optimizing growth in children with chronic kidney disease. // Front Pediatr. 2020;8:399.
  10. Iorember FM. Malnutrition in chronic kidney disease. // Front Pediatr. 2018;6:161.
  11. Thapa BK, Bhatia P, Meena J, et al. Prevalence and risk factors for functional iron deficiency in children with CKD. // Clin Exp Nephrol. 2023;27(1):66-71.
  12. Atkinson MA, Martz K, Warady BA, Neu AM. Risk for anemia in pediatric CKD patients: a report of NAPRTCS. // Pediatr Nephrol. 2010;25(9):1699-1706.
  13. Harambat J, van Stralen KJ, Kim JJ, Tizard EJ. Epidemiology of chronic kidney disease in children. Pediatr Nephrol. 2012;27(3):363-373.
  14. Warady BA, Abraham AG, Schwartz GJ, et al. Predictors of rapid progression in pediatric CKD. // Pediatr Nephrol. 2015;30(11):2017-2025.
  15. Wong H, Mylrea K, Feber J, et al. Prevalence of complications in children with CKD according to KDOQI. Kidney Int. 2006;70(3):585-590[62].
  16. Mkrtchyan N, et al. Sleep disorders and executive function in children and adolescents with CKD. Int J Pediatr. 2018;2018:ID 5453871.
  17. Furth SL, et al. Effect of renal transplantation on intellectual achievement in children with ESRD. // Pediatr Nephrol. 2010;25(4):769-775.
  18. Kidney Disease: Improving Global Outcomes (KDIGO). Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. // Kidney Int Suppl. 2013;3(1):1-150.
  19. Tain YL, Hsu CN. Cardiovascular risks of hypertension: lessons from children with CKD. // Children (Basel). 2022;9(11):1650.
  20. Hartung EA, et al. Age-related changes in brain structure in pediatric CKD. // Clin J Am Soc Nephrol. 2020;15(5):695-703.

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