62 -11 (85) 2025 - Rakhmatullaev A.A., Aripova T.U. - IMMUNE CELLS, INFLAMMATORY CYTOKINES, AND AUTOANTIBODIES TO CARDIAC TISSUE IN DILATED CARDIOMYOPATHY

IMMUNE CELLS, INFLAMMATORY CYTOKINES, AND AUTOANTIBODIES TO CARDIAC TISSUE IN DILATED CARDIOMYOPATHY

Rakhmatullaev A.A. - Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan

Aripova T.U. - Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan

Kim A.A. - Samarkand State Medical University

Ziyadullaev Sh.Kh. - Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan

Ismailova A.A. - Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan

Khatamov Kh.M. - Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan

Resume

The aim of this study was to investigate the expression patterns of lymphocyte subsets, proinflammatory cytokines, and cardiac autoantibodies in patients with dilated cardiomyopathy (DCM). The study included 57 patients with DCM and 29 healthy controls. Immunological parameters were assessed using flow cytometry, enzyme-linked immunosorbent assay, and indirect immunofluorescence. Patients with DCM showed an increase in the total leukocyte count and absolute T-lymphocyte count, along with a decrease in the relative content of CD3⁺, CD16⁺, and CD19⁺ cells, as well as a significant increase in the proportion of CD8⁺ cytotoxic lymphocytes, resulting in a decrease in the CD4⁺/CD8⁺ ratio. A sharp increase in levels of circulating immune complexes, myocardial and mitochondrial autoantibodies, and the cytokines IL-6 and TNF-α was observed. These data indicate the activation of autoimmune and inflammatory mechanisms that play a key role in the pathogenesis of dilated cardiomyopathy. Identification of these immunological abnormalities may have diagnostic and prognostic value and serve as a basis for the development of personalized immunotherapeutic approaches for this disease.

Key words: dilated cardiomyopathy, immune cells, inflammatory cytokines, autoantibodies, circulating immune complexes, T lymphocytes, IL-6, TNF-α.

First page

369

Last page

374

For citation:Rakhmatullaev A.A., Aripova T.U., Kim A.A., Ziyadullaev Sh.Kh., Ismailova A.A., Khatamov Kh.M. - IMMUNE CELLS, INFLAMMATORY CYTOKINES, AND AUTOANTIBODIES TO CARDIAC TISSUE IN DILATED CARDIOMYOPATHY//New Day in Medicine 11(85)2025 369-374 https://newdayworldmedicine.com/en/new_day_medicine/11-85-2025

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