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63 -11 (85) 2025 - Avazov J.O., Aripova T.U. - G197A POLYMORPHISMS OF THE INFLAMMATORY CYTOKINE IL-17A GENE IN ATOPIC DERMATITIS

G197A POLYMORPHISMS OF THE INFLAMMATORY CYTOKINE IL-17A GENE IN ATOPIC DERMATITIS

Avazov J.O. - Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan

Aripova T.U. - Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan

Kim A.A. - Samarkand State Medical University

Ziyadullaev, Sh.Kh. - Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan

Ruzibakieva, M.R. - Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan

Khatamov Kh.M. - Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan

Resume

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a strong genetic predisposition and multifactorial pathogenesis. Particular attention is paid to the role of cytokines, including IL-17A, in the immune-inflammatory response in AD. The aim of this study was to investigate the association of the IL-17A gene G-197A polymorphism (rs2275913) with susceptibility to atopic dermatitis in the Uzbek population. The study included 102 patients with AD and 72 healthy controls. Genotyping was performed using allele-specific PCR. The distribution of IL-17A G-197A allele and genotype frequencies revealed no statistically significant differences between groups (p>0.05). Genotype frequencies corresponded to Hardy-Weinberg equilibrium, confirming the accuracy of the typing. Thus, the obtained results indicate the absence of a significant association between the IL-17A G-197A polymorphism and susceptibility to AD in the studied population. Differences with the results of other studies may be due to ethnic characteristics and the complex polygenic nature of the disease. These data supplement the existing knowledge on the role of cytokine genes in the immunogenetic mechanisms of AD and highlight the need for further studies on larger samples taking into account clinical phenotypes.

Keywords: atopic dermatitis, IL-17A, gene polymorphism, rs2275913, genetic predisposition, cytokines

First page

375

Last page

380

For citation:Avazov J.O., Aripova T.U., Kim A.A., Ziyadullaev, Sh.Kh., Ruzibakieva, M.R., Khatamov Kh.M. - G197A POLYMORPHISMS OF THE INFLAMMATORY CYTOKINE IL-17A GENE IN ATOPIC DERMATITIS//New Day in Medicine 11(85)2025 375-380 https://newdayworldmedicine.com/en/new_day_medicine/11-85-2025

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