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  • 4 -12 (86) 2025 - Mukhitdinova Kh.N., Shomurodov A.Y. - “SPECIFIC FEATURES OF THE IMPACT OF STRESS-PROTECTIVE THERAPY ON THE CIRCADIAN RHYTHM OF MYOCARDIAL OXYGEN DEMAND AND THE CIRCADIAN RESPONSE OF AUTONOMIC TONE IN CHILDREN OVER 7 YEARS WITH SEVERE COM

4 -12 (86) 2025 - Mukhitdinova Kh.N., Shomurodov A.Y. - “SPECIFIC FEATURES OF THE IMPACT OF STRESS-PROTECTIVE THERAPY ON THE CIRCADIAN RHYTHM OF MYOCARDIAL OXYGEN DEMAND AND THE CIRCADIAN RESPONSE OF AUTONOMIC TONE IN CHILDREN OVER 7 YEARS WITH SEVERE COM

“SPECIFIC FEATURES OF THE IMPACT OF STRESS-PROTECTIVE THERAPY ON THE CIRCADIAN RHYTHM OF MYOCARDIAL OXYGEN DEMAND AND THE CIRCADIAN RESPONSE OF AUTONOMIC TONE IN CHILDREN OVER 7 YEARS WITH SEVERE COMBINED TRAUMATIC BRAIN INJURY

Mukhitdinova Kh.N. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Shomurodov A.Y. - 2nd Children’s Surgical Clinical Hospital of Tashkent

Resume

Group 2 had higher ISS scores (29.8±4.0 vs. 23.1±5.7) and lower Glasgow scores (7.4±1.4 vs. 9.7±1.6), indicating more severe injuries. Overall MOD circadian rhythm differences were not significant; however, Group 2 showed increased sympathetic activity and greater MOD variability on Days 8, 9, and after Day 19. Stress-protective therapy with stable plasma concentrations of fentanyl, propofol, and arduan effectively supported myocardial function and stabilized MOD during peak inflammatory periods. Strong correlations were observed between MOD fluctuations and sympathetic activity, emphasizing the importance of targeted metabolic and cardiotropic support.

Keywords: severe combined traumatic brain injury, children, myocardial oxygen demand, autonomic tone, circadian rhythm, stress-protective therapy

First page

18

Last page

22

For citation:Mukhitdinova Kh.N., Shomurodov A.Y. - “SPECIFIC FEATURES OF THE IMPACT OF STRESS-PROTECTIVE THERAPY ON THE CIRCADIAN RHYTHM OF MYOCARDIAL OXYGEN DEMAND AND THE CIRCADIAN RESPONSE OF AUTONOMIC TONE IN CHILDREN OVER 7 YEARS WITH SEVERE COMBINED TRAUMATIC BRAIN INJURY//New Day in Medicine 12(86)2025 18-22 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

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