6 -12 (86) 2025 - Fatilloyeva G.Z. - PATHOLOGICAL CHANGES IN ADRENAL GLAND FUNCTION UNDER THE INFLUENCE OF EXTERNAL FACTORS

PATHOLOGICAL CHANGES IN ADRENAL GLAND FUNCTION UNDER THE INFLUENCE OF EXTERNAL FACTORS

Fatilloyeva G.Z. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This article examines the impact of external factors on adrenal gland function. External factors include infections, medications, traumas, environmental pollutants, and stress. Through this review, the causes and mechanisms of pathological changes are elucidated, aiding in better clinical diagnosis and treatment. Based on the literature, infections can destroy the adrenal cortex, medications can disrupt hormone synthesis, and environmental factors can lead to chronic alterations. Consequently, conditions such as adrenal insufficiency or hormone excess develop.

Keywords: adrenal glands, external factors, pathological changes, infections, medications, environmental impact, adrenal insufficiency, Cushing's syndrome.

First page

28

Last page

33

For citation:Fatilloyeva G.Z. - PATHOLOGICAL CHANGES IN ADRENAL GLAND FUNCTION UNDER THE INFLUENCE OF EXTERNAL FACTORS//New Day in Medicine 12(86)2025 28-33 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

List of References

  1. Heim C., Nemeroff C.B. (2000). The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. // Psychoneuroendocrinology 2000;25(1):1-35. https://doi.org/10.1016/s0306-4530(99)00035-9
  2. Yaglova N.V., Obernikhin S.S., Nazimova S.V., Timokhina E.P., Yaglov V.V. (2020). Changes in transcriptional regulation of postnatal morphogenesis of the adrenal zona fasciculata caused by endocrine disruptor dichlorodiphenyltrichloroethane. Bulletin of Experimental Biology and Medicine, 2020;168(6):797-801. https://doi.org/10.1007/s10517-020-04805-w
  3. Wang T., Li J., Zhang Y. (2017). The inhibiting effect of intravenous anesthesia on adrenal gland functions under the sepsis condition. // International Journal of Immunopathology and Pharmacology, 30(2), 188–193. https://doi.org/10.1177/0394632017705049
  4. Amar L., Baudin E., Bertherat J., Ajzenberg C., Bille-Turc F., Lacave R., Bertagna X. (2005). Year of diagnosis, features at presentation, and risk of recurrence in patients with pheochromocytoma or secreting paraganglioma. // The Journal of Clinical Endocrinology Metabolism, 2005;90(4):2110–2116. https://doi.org/10.1210/jc.2004-1398
  5. Villa R. F., Herrera-Mundo M. E., Barriga C. (2012). Energy metabolism of rat cerebral cortex, hypothalamus and hypophysis during ageing. Neuroscience, 2012;227:55-66. https://doi.org/10.1016/j.neuroscience.2012.09.041
  6. Chahal H.S., Filer, A. (2007). The endocrine system and ageing. // Journal of Pathology, 2007;211(2):173–180. https://doi.org/10.1002/path.2110
  7. Sonino N., Fava G. A., Ferrara A. (1988). Stressful life events in the pathogenesis of Cushing's syndrome. // Clinical Endocrinology 1988;29(6):617-623. https://doi.org/10.1111/j.1365-2265.1988.tb03709.x
  8. Altmeyer P. (1977). [Histology of skin changes caused by external corticoid preparations]. // Hautarzt, 1977;28(2):83-88. https://pubmed.ncbi.nlm.nih.gov/403157/
  9. Schweigerer L., Neufeld G., Dröge C., Friedman J., Abraham J. A., Fiddes J. C., Gospodarowicz D. (1987). Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. // Nature, 1987;325(6101):257-259. https://doi.org/10.1038/325257a0
  10. Xekouki P., Stratakis C. A., Korbonits M. (2019). The 3PAs: An update on the association of pheochromocytomas, paragangliomas, and pituitary tumors. // Hormone and Metabolic Research, 2019;51(7):419-436. https://doi.org/10.1055/a-0661-0341
  11. Pitsava G., Maria A. G., Faucz F. R. (2022). Disorders of the adrenal cortex: Genetic and molecular aspects. // Frontiers in Endocrinology 2022;13: Article 931389. https://doi.org/10.3389/fendo.2022.931389
  12. Huecker M., Bhutta B., Dominique E. (2023). Adrenal insufficiency. In StatPearls. // StatPearls Publishing 2023. https://www.ncbi.nlm.nih.gov/books/NBK441832/
  13. Gauss C., Rowland D., Ergun-Longmire B. (2022). An update on genetics of adrenal gland and associated disorders. Endocrines 2022;3(2):187-197. https://doi.org/10.3390/endocrines3020017
  14. Abdellatif A. B., Fernandes-Rosa F. L., Boulkroun S., Zennaro, M.-C. (2022). Vascular and hormonal interactions in the adrenal gland. // Frontiers in Endocrinology 2022;13:Article 995228. https://doi.org/10.3389/fendo.2022.995228
  15. Kumar R., Wassif W. S. (2022). Adrenal insufficiency. // Journal of Clinical Pathology 2022;75(7):435. https://doi.org/10.1136/jclinpath-2021-207997
  16. Lacroix A., Hamet P., Boutin J.M. (1999). Leuprolide acetate therapy in luteinizing hormone–dependent Cushing's syndrome. // New England Journal of Medicine 1999;341(21):1577-1581. https://doi.org/10.1056/NEJM199911183412104
  17. Reznik Y., Allali-Zerah V., Chayvialle J. A., Leroyer R., Leymarie P., Travert G., Lebrethon, M. C. (1992). Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide. // New England Journal of Medicine, 1992;327(14):981-986. https://doi.org/10.1056/NEJM199210013271403
  18. Vezzosi D., Cartier D., Régnier C., Otal P., Bennet A., Parmentier F., Plantavid M. (2007). Familial adrenocorticotropin-independent macronodular adrenal hyperplasia with aberrant serotonin and vasopressin adrenal receptors. // European Journal of Endocrinology 2007;156(1):21-31. https://doi.org/10.1530/eje.1.02324
  19. Libé R., Coste J., Guignat L., Tissier F., Lefebvre H., Barrande G., Bertherat J. (2010). Aberrant cortisol regulations in bilateral macronodular adrenal hyperplasia: A frequent finding in a prospective study of 32 patients with overt or subclinical Cushing's syndrome. // European Journal of Endocrinology 2010;163(1):129-138. https://doi.org/10.1530/EJE-10-0195
  20. Hofland J., Hofland L.J., van Koetsveld P.M., Steenbergen J., de Herder W.W., van Eijck C.H., Feelders R.A. (2013). ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitro responses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase. // Orphanet Journal of Rare Diseases, 2013;8:Article 142. https://doi.org/10.1186/1750-1172-8-142

    file

    download