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13 -12 (86) 2025 - Kholov Kh.N. - FEATURES OF THE CLINICAL COURSE OF CHRONIC PURULENT RHINOSINUSITIS IN COMBINATION WITH METABOLIC SYNDROME

FEATURES OF THE CLINICAL COURSE OF CHRONIC PURULENT RHINOSINUSITIS IN COMBINATION WITH METABOLIC SYNDROME

Kholov Kh.N. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The purpose of this study was to study the relationship between the immune profile and the metabolic syndrome in patients with chronic purulent rhinosinusitis. A comprehensive analysis of clinical, immunological and biochemical parameters was performed in patients suffering from chronic inflammation of the paranasal sinuses, accompanied by purulent secretion. The levels of pro-inflammatory and anti-inflammatory cytokines, immunoglobulins of various classes, as well as parameters of metabolic metabolism, including lipid and carbohydrate spectra, were studied. It was found that patients with a combination of chronic rhinosinusitis and metabolic syndrome have a pronounced imbalance of the immune response, manifested by an increase in the concentration of IL-6, TNF-α, IgE and a decrease in the level of IL-10, which correlates with the severity of the clinical course of the disease. The data obtained confirm the existence of a close relationship between metabolic disorders and changes in the body's immune reactivity, which determines the need for an integrated approach to the diagnosis and treatment of such patients.

Key words: chronic purulent rhinosinusitis, cytokines, metabolic syndrome.

First page

64

Last page

72

For citation:Kholov Kh.N. - FEATURES OF THE CLINICAL COURSE OF CHRONIC PURULENT RHINOSINUSITIS IN COMBINATION WITH METABOLIC SYNDROME//New Day in Medicine 12(86)2025 64-72 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

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