81 -9 (59) 2023 - Sharipova I.P., Yuldashova G.T. - PROSPECTS FOR EARLY DIAGNOSIS OF CERVICAL CANCER

PROSPECTS FOR EARLY DIAGNOSIS OF CERVICAL CANCER

Sharipova I.P. - Scientific Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases

Yuldashova G.T. - Scientific Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases

Sidirova Sh.S. - Scientific Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases

Rakhimov R.A. - Scientific Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases

Suyarkulova D.T.- Scientific Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases

Gareev R.F. - Scientific Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases

Sharapov S.M. - Scientific Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases

Turabova N.R. - Scientific Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases

Akhmedova Sh.X. - Scientific Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases

Resume

Screening women for HPV, in combination with liquid cytology, carried out on a mandatory and regular basis, allows 57.1% of women infected with HPV to identify in the early stages possible oncological risks of the most common neoplasms of the cervical canal, amenable to preventive therapy. Cervical smears were examined by PCR for the presence of HPV DNA - 39,740 women aged over 30 years and 1,908 of them had liquid cytology for early diagnosis of cervical cancer. The present study showed that the HPV infection rate was 11.2%. All HPV isolated in the collected samples belong to high oncogenic risk genotypes. Based on the results of liquid cytology, 15 women examined (0.8%) were diagnosed with an already irreversible stage of cervical cancer.

Key words: Human papilloma virus, Screening, Cervical cancer, procalcitonin

First page

445

Last page

450

For citation: Sharipova I.P., Yuldashova G.T., Sidirova Sh.S., Rakhimov R.A., Suyarkulova D.T., Gareev R.F., Sharapov S.M., Turabova N.R., Akhmedova Sh.X. – PROSPECTS FOR EARLY DIAGNOSIS OF CERVICAL CANCER//New Day in Medicine 2023 9(59): 445-450 https://newdaymedicine.com/index.php/2023/10/18/l-465/

LIST OF REFERENCES:

  1. Добровольская Д. А., Байрамова Г. Р., Асатурова А. В., Теврюкова Н. С. Прогностическая значимость биомаркеров вируса папилломы человека в дифференциальной диагностике плоскоклеточных интраэпителиальных поражений шейки матки. // Акушерство и гинекология. 2022;6:20-25.
  2. Пантеева Я.И., Артамонов Р.П. Роль вируса папилломы человека в развитии рака шейки матки // Бюллетень медицинских интернет-конференций. 2019;9(9):374-375.
  3. Тилляшайхов М.Н., Ибрагимов Ш.Н., Джанклич С.М. Онкологическая служба Республики Узбекистан: анализ заболеваемости и смертности // Онкологический журнал. 2021;15/2(58):74-80.
  4. Anantharaman D, Abedi-Ardekani B, Beachler DC, Gheit T, Olshan AF, Wisniewski K, et al. (2018). "Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer". International Journal of Cancer. 2018;140(9):1968-1975. doi:10.1002/ijc.30608.
  5. Approaches for triaging women who test positive for human papillomavirus in cervical cancer screening. JMIR Mhealth Uhealth. May 29 2019;5(5):e72. doi: 10.2196/mhealth.6697.
  6. Chen G., Zheng P., Gao L., Zhao J., Wang Y, Qin W. Prevalence and genotype distribution of human papillomavirus in women with cervical cancer or cervical intraepithelial neoplasia in Henan province, central China. // J. Med. Virol. 2020;92(12):3743-9. https://dx.doi.org/10.1002/jmv.25670.
  7. Gearhart P. A. Human Papillomavirus Guidelines. MBBS, 2020, MD. Medscape.com.
  8. Satanova A.R., Kaidarova D.R., Kukubassov E.K., Bolatbekova R.O., Kaldybekov D.B., Bertleuov O.O. The global prevalence of human papillomavirus causing cervical cancer: a literature review // Oncology and radiology of Kazakhstan. 2022;3(65):42-46. DOI: 10.52532/2663-4864-2022-3-65-42-46.
  9. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. // CA Cancer J Clin. 2021:71:209–49. doi:10.3322/caac.21660.

    file

    download