• Home
  • NEW DAY MEDICINE
  • 9 (59) 2023
  • 84 -9 (59) 2023 - Sadulloeva I.K., Obloqulov A.R. - CYTOKINE STATUS IN PATIENTS WITH SARS-CoV-2 PNEUMONIA AND TYPE 2 DIABETES

84 -9 (59) 2023 - Sadulloeva I.K., Obloqulov A.R. - CYTOKINE STATUS IN PATIENTS WITH SARS-CoV-2 PNEUMONIA AND TYPE 2 DIABETES

CYTOKINE STATUS IN PATIENTS WITH SARS-CoV-2 PNEUMONIA AND TYPE 2 DIABETES

Sadulloeva I.K. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Obloqulov A.R. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Aslanova M.R. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The cytokine status of patients with SARS CoV-2 pneumonia and type 2 diabetes was studied. In the study, 103 patients hospitalized with SARS CoV-2 pneumonia at the Bukhara Regional Infectious Diseases Hospital, which was converted into a Covid-center, were involved. Immunological examination of elderly patients was carried out in the immunomorphology laboratory of the Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan. Indicators of cytokine (IL-4, IL-18) status in the blood were studied. The results showed an increase in the synthesis of IL-4, IL-18 in patients of control groups. A significant increase in IL-4 synthesis was found in patients with type 2 diabetes, which was independent of the severity of coronavirus pneumonia and the presence of diabetes. In the study, we found an increase in the amount of IL-18 in the blood of patients, regardless of the severity of covid pneumonia and the presence of diabetes.

Key words: SARS CoV-2, diabetes type 2, immunized, cytokine, pneumonia., procalcitonin

First page

460

Last page

466

For citation: Sadulloeva I.K., Obloqulov A.R., Aslanova M.R. – CYTOKINE STATUS IN PATIENTS WITH SARS-CoV-2 PNEUMONIA AND TYPE 2 DIABETES//New Day in Medicine 2023 9(59): 460-466 https://newdaymedicine.com/index.php/2023/10/18/l-465/

LIST OF REFERENCES:

  1. Baltzis, D. Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights / D. Baltzis, I. Eleftheriadou, A. Veves // Advances Therapy. 2014;31(8):817-836. – doi: 10.1007/s12325- 014-0140-x.
  2. Diabetes Impairs the Late Inflammatory Response to Wound Healing / T. J. Fahey [et al.] // The Journal of Surgical Research. 1991;50(4):308-313. – doi: 10.1016/0022-4804(91)90196-s
  3. Effects of Acute Diabetes on Rat Cutaneous Wound Healing / M. C. Komesu [et al.] // Pathophysiology. 2004;11(2):63-67. – doi: 10.1016/j.pathophys.2004.02.002.
  4. Effects of Acute Diabetes on Rat Cutaneous Wound Healing / M. C. Komesu [et al.] // Pathophysiology. 2004;11(2):63-67. – doi: 10.1016/j.pathophys.2004.02.002
  5. Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – a systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr. 2020;14(4):395–403. doi: https://doi.org/10.1016/j.dsx.2020.04.018
  6. Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia /E. G. Lee [et al.] // Journal of Immunology Research. 2019;5087847:1-9. – doi: 10.1155/2019/5087847.
  7. Implication of Interleukin-4 in Wound Healing / V. Salmon-Her [et al.] // Laboratory Investigation. 2000;80:1337-1343. – doi: 10.1038/ labinvest.3780141.
  8. Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia /E. G. Lee [et al.] // Journal of Immunology Research. 2019;5087847:1-9. – doi: 10.1155/2019/5087847
  9. Mirza R. Dysregulation of Monocyte/Macrophage Phenotype in Wounds of Diabetic Mice / R. Mirza, T. J. Koh // Cytokine. 2011;56(2):256-264. – doi: 10.1016/j.cyto.2011.06.016.]
  10. Petrillo MG, Bortner C, Cidlowski JA. Glucocorticoids: inflammation and immunity. The HypothalamicPituitary-Adrenal Axis in Health and Disease. 2017;43-63.doi: https://doi.org/10.1007/978-3-319-45950-9_

    file

    download