46 -12 (86) 2025 - Nabiyeva D.A. Usmanov U.R. - ASSOCIATION OF EXCESS WEIGHT WITH OSTEOARTHRITIS

ASSOCIATION OF EXCESS WEIGHT WITH OSTEOARTHRITIS

Nabiyeva D.A. - Tashkent State Medical University

Usmanov U.R. - Urgench Branch of Tashkent State Medical University

Khayitboeva K.Kh. - Urgench Branch of Tashkent State Medical University

Resume

Recent studies have established an association between obesity and the development of knee osteoarthritis that goes beyond the increased mechanical load on the knees as weight-bearing joints. This link is based on the maintenance of a chronic low-grade inflammation, altered secretion of adipokines by the adipose tissue and development of sarcopenia. Major adipokines involved in the pathogenesis of obesity-related knee osteoarthritis include adiponectin, which appears to have a protective effect, as well as leptin, resistin and visfatin, which are associated with higher pain scores and more severe structural damage. The aim of the present review is to highlight major pathogenic mechanisms in obesity-related knee osteoarthritis and to comment on possible therapeutic approaches.

Keywords: osteoarthritis, cartilage degeneration, obesity

First page

258

Last page

266

For citation:Nabiyeva D.A. Usmanov U.R. Khayitboeva K.Kh. - ASSOCIATION OF EXCESS WEIGHT WITH OSTEOARTHRITIS//New Day in Medicine 12(86)2025 258-266 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

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