63 -2 (40) 2022 — Daminova Kh.M., Saidvaliev F.S. — ASSESSMENT OF OLFACTORY FUNCTION IN THE STUDY GROUPS AND THEIR ROLE IN THE PROGRESSION OF THE DISEASE
OLFACTORY FUNCTION DISTURBANCES IN THE STUDYED GROUPS AND THEIR ROLE IN DISEASE PROGRESSION
Daminova Kh.M., Tashkent Medical Academy, Uzbekistan
Saidvaliev F.S. Tashkent Medical Academy, Uzbekistan
Resume
The article presents the results of observation of 213 patients with PD, including 90 (42.25%) women, 123 (57.75%) men, whose mean age was 46.17±0.63 years. Patients with PD were selected in accordance with the international criteria of the British brain bank “Parkinson’s Disease Society Brain Bank”. Patients underwent CT or MRI of the brain. Olfactory disturbances were studied using the Sniffin Stix Test (SST) by Burchard (Hamburg, Germany). All patients underwent examination of the ENT organs. The results obtained indicate that the presence of hyposmia in patients with early onset of PD is an important biomarker of the latent neurodegenerative process of the “Parkinsonian” type and, therefore, the risk of future development of PD.
Key words: Parkinson’s disease, olfactory function, brain, hyposmia, anosmia.
First page
330
Last page
332
For citation: Daminova Kh.M., Saidvaliev F.S. OLFACTORY FUNCTION DISTURBANCES IN THE STUDYED GROUPS AND THEIR ROLE IN DISEASE PROGRESSION //New Day in Medicine 2(40)2022 330-332 https://cutt.ly/rAKKplz
LIST OF REFERENCES:
- Daminova X.M. Modern view to optimization of the diagnosis of the course of parkinson’s disease //New Day in Medicine 1(39)2022 115-118 https://cutt.ly/KOerez1
- Morozova S.V., Savvateeva D.M., Lopatin A.S. Disorders of sense of smell and their correction // Herald of otorinolaryngology. – 2012. – № 5. – p. 66-70.
- Schtok V.N., Fedorova N.V. Parkinson’s disease // Extrapyramidal disorders: Hand-in diagnostics and treatment / ed. V.N. Stem, I.A. Ivanova-Smolenskaya, O.S. Levin. M.: Medpress-Inform, 2012. P. 87-124.
- Alonso-Navarro H., Jimenez-Jimenez F.J., Garcia-Martin E., Agundez J.A.G. Genomic and pharmacogenomics biomarkers of Parkinson’s disease // Cur. Drug Metab. 2014. – Vol. 15. – P. 129-181.
- Ponomarev V.V. Lab biomarkers of early diagnosis of Parkinson’s disease / V.V. Ponomarev, A.V. Boyko, O.A. Ionova // International Neurological Journal. – 2016. – №3 (81). – from. 54-58.
- Braak H. Staging of brain pathology related to sporadic Parkinson’s disease / Braak H., Del Tredici K., Rüb U., de Vos R.A.I., Jansen Steur E.N.H, Braak // Neurobiol Aging.–2013–Vol.24–р.197–210.
- Duda J.E. Olfactory system pathology as a model of Lewy neurodegenerative disease // J. Neurol. Sci. – 2017. – Vol. 289. – P. 49-54.
- Eibenstein А., Fioretti A.B., Lena C. et al. Modern psychophysical tests to assess olfactory function // Neurol. Sci. – 2015. – Vol. 26. – P. 147-155.
- Xu Y. Meta-analysis of risk factors for Parkinson’s disease dementia.A 10-year study of the incidence of and factors predicting dementia in Parkinson’s disease / Xu Y., Yang J., Shang H. // Тranslational Neurodegeneration [Transl Neurodegener] – 2016 – Jun 01 –Vol. 5 –p. 11.