66 -12 (86) 2025 - Nurulloyev S.O. - IMPACT OF ACUTE IONIZING RADIATION ON PATHOMORPHOLOGICAL CHANGES IN THE KIDNEYS OF WHITE OUTBRED RATS

IMPACT OF ACUTE IONIZING RADIATION ON PATHOMORPHOLOGICAL CHANGES IN THE KIDNEYS OF WHITE OUTBRED RATS

Nurulloyev S.O. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This study investigated the effects of acute ionizing radiation on pathomorphological changes in the kidney tissue of white outbred rats. Histological preparations obtained from the kidneys of laboratory animals exposed to a single total dose of 5 Gray were examined microscopically. The results revealed several pathological features, including pale pink coloration of the medullary epithelium, hydropic degeneration and focal necrotic lesions in tubular epithelium, deformation of renal glomeruli, as well as congestion of subcapsular and perilobular vessels. Narrowing of Bowman’s space and accumulation of homogeneous protein masses within proximal tubules indicated marked impairment of renal filtration and reabsorption functions. The absence of such changes in intact animals confirms the significant structural damage caused by acute radiation exposure. These findings provide an important scientific basis for a deeper understanding of morphological processes that develop under short-term, high-dose ionizing radiation.

Keywords: Acute radiation, ionizing radiation, white outbred rats, kidney morphology, hydropic degeneration, focal necrosis, glomerular deformation, Bowman’s space, histological changes, pathomorphology

First page

369

Last page

377

For citation:Nurulloyev S.O. - IMPACT OF ACUTE IONIZING RADIATION ON PATHOMORPHOLOGICAL CHANGES IN THE KIDNEYS OF WHITE OUTBRED RATS//New Day in Medicine 12(86)2025 369-377 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

List of References

1. Abrashova T.V., Guщin Ya.A., Kovaleva M.A., Rыbakova A.V., Selezneva A.I., Sokolova A.P., Xodko S.V. Spravochnik. Fiziologicheskie, bioximicheskie i biometricheskie pokazateli normы eksperimentalnыx jivotnыx. SPB: Izd-vo «Lema». 2013; 116 str.
2. Artashyan O.S., Yushkov B.G., Xramsova Yu.S. Morfologicheskie aspektы uchastiya tuchnыx kletok v formirovanii obщego adaptasionnogo sindroma // Tavricheskiy mediko-biologicheskiy vestnik. 2012;15(3-1):22-25.
3. Arxipova L.V., Glazkova P.A., Glazkov A.A., Bыchenkov O.A., Kulikov D.A. Sposob snijeniya letalnosti ot radiasionnogo vozdeystviya u eksperimentalnыx jivotnыx. Data registrasii: 17.01.2019.
4. Safonova V.Yu., Safonova V.A. Vliyanie ioniziruyuщego izlucheniya v nizkoy doze na gistomorfologiyu pecheni krыs // Izvestiya Orenburgskogo GAU. – Orenburg. 2008;4(20):122-124.
5. Saluxov V.V., Legeza V.I., Pershko V.A. Eksperimentalnoe izuchenie protivoluchevыx svoystv granulotsitarnogo kolonie-stimuliruyuщego faktora // Rentgenologiya i radiologiya. 2013;14:1-15.
6. Saruxanov V.Ya., Kolganov I.M., Yepimaxov V.G. Sravnitelnaya otsenka radiochuvstvitelnosti jivotnыx raznыx vidov // Radiasionnaya biologiya. Radioekologiya. 2016;56(5):475-480.
7. Wang L., Li X. Radioprotective effect of Hohenbuehelia serotina polysaccharides through mediation of ER apoptosis pathway in vivo // Int J Biol Macromol. 2019;127:18-26.
8. Wang W., Xue C., Mao X. Radioprotective effects and mechanisms of animal, plant and microbial polysaccharides // Int J Biol Macromol. 2020;153:373-384.
9. Wegner R.E., Abel, S., Vemana, G., Mao, S., Fuhrer, R. (2020). Utilization of Stereotactic Ablative Body Radiation Therapy for Intact Renal Cell Carcinoma: Trends in Treatment and Predictors of Outcome // Advances in Radiation Oncology. 2020;5(1):85-91.
10. Xiaochun X., Baixia, Xiaogang Zh. Prognostic Role of microRNA-21 in Colorectal Cancer: a Meta-Analysis // PLoS One. 2013;8(11):e80426.

    file

    download