78 -12 (86) 2025 - Nematov J.B., Zaripova O.O. - ASSESSMENT OF THE IMPACT OF NANOPARTICLES OF VARIOUS CHEMICAL NATURE ON THE ORGANISM

ASSESSMENT OF THE IMPACT OF NANOPARTICLES OF VARIOUS CHEMICAL NATURE ON THE ORGANISM

Nematov J.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Zaripova O.O. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Recently, an increased interest in nanotechnology applications can be observed in various fields (medicine, materials science, pharmacy, environmental protection, agriculture etc.). Due to an increasing scope of applications, the exposure of humans to nanoparticles (NPs) is inevitable. They can also have a genotoxic effect leading to, among others, apoptosis or chromosomal instability. This paper gives a review of previous studies concerning the effects of exposure to TiO2 NPs on a living organism (human, animal). This information is necessary in order to demonstrate potential toxicity of inorganic nanoparticles on human health.

Keywords: environment, nanoparticles (NPs), homeostasis, oral exposure

First page

433

Last page

435

For citation:Nematov J.B., Zaripova O.O. - ASSESSMENT OF THE IMPACT OF NANOPARTICLES OF VARIOUS CHEMICAL NATURE ON THE ORGANISM//New Day in Medicine 12(86)2025 433-435 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

List of References

1. Świdwińska-Gajewska AM, Czerczak S (2014) Titanium dioxide nanoparticles—biological effects. Med Pr 65:651–663 https:// www.ncbi.nlm.nih.gov/pubmed/25230569
2. Pandey RK, Prajapati VK (2017) Molecular and immunological toxic effects of nanoparticles. Int J Biol Macromol 107:1278– 1293. https://doi.org/10.1016/j.ijbiomac.2017.09.110
3. Allen R (2016) The cytotoxic and genotoxic potential of titanium dioxide (TiO2) nanoparticles on human SH-SY5Y neuronal cells in vitro. The Plymouth Student Scientist 9:5–28 http://bcur.org/ journals/index.php/TPSS/article/view/575 4. Samat MH, Ali AMM, Taib MFM, Hassan OH, Yahya MZA (2016) Hubbard U calculations on optical properties of 3d transition metal oxide TiO2. Results in Phys 6:891–896. https://doi.org/10. 1016/j.rinp.2016.11.006
4. Bourikas K, Kordulis C, Lycourghiotis A (2014) Titanium dioxide (anatase and rutile): surface chemistry, liquid-solid interface chemistry, and scientific synthesis of supported catalysts. Chem Rev 114: 9754–9823. https://doi.org/10.1021/cr300230q
5. Weir A, Westerhoff P, Fabricius L, Hristovski K, von Goetz N (2012) Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46:2242–2250. https://doi.org/10. 1021/es204168d
6. Hong F, Yu X, Wu N, Yu-Qing Zhang YQ (2017) Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles. Toxicol Res 6:115–133. https://doi.org/10.1039/ c6tx00338a
7. Shi H, Magaye R, Castranova V, Zhao J (2013) Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 10:15. https://doi.org/10.1186/1743-8977-10-15
8. Lim JH, Sisco P, Mudalige TK, Sánchez-Pomales G, Howard PC, Linder SW (2015) Detection and characterization of SiO2 and TiO2 nanostructures in dietary supplements. J Agric Food Chem 63: 3144–3152. https://doi.org/10.1021/acs.jafc.5b00392
9. Rai M, Ribeiro C, Mattoso L, Duran N (2015) Nanotechnologies in food and agriculture. Springer International Publishing Switzerland, pp 352. https://www.springer.com/kr/book/ 9783319140230
10. Heringa MB, Geraets L, van Eijkeren JC, Vandebriel RJ, de Jong WH, Oomen AG (2016) Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations. Nanotoxicology 11:1–11. https://doi.org/10.1080/17435390.2016.1238113

    file

    download