104 -12 (86) 2025 - Khojiev B.B. - CHOLECYSTECTOMY AS A RISK FACTOR FOR NON-ALCOHOLIC FATTY LIVER DISEASE DEVELOPMENT

CHOLECYSTECTOMY AS A RISK FACTOR FOR NON-ALCOHOLIC FATTY LIVER DISEASE DEVELOPMENT

Khojiev B.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Cholecystectomy, the surgical removal of the gallbladder, is commonly performed for gallstones or cholecystitis. Recent evidence suggests that it may contribute to the development of non-alcoholic fatty liver disease (NAFLD). The gallbladder plays a key role in regulating bile acid release, which is important for lipid and glucose metabolism. After cholecystectomy, continuous bile flow can disrupt bile acid signaling, potentially leading to hepatic fat accumulation and insulin resistance. Additionally, gallbladder removal can alter gut microbiota and exacerbate metabolic risk factors such as obesity, diabetes, and hyperlipidemia, further increasing NAFLD risk. Observational studies report higher rates of NAFLD in post-cholecystectomy patients, especially those with pre-existing metabolic syndrome. Clinically, monitoring liver function and promoting lifestyle interventions, including weight management, diet, and physical activity, are recommended to reduce NAFLD risk in these patients. Cohort and retrospective studies have shown that patients who undergo cholecystectomy have a higher incidence of NAFLD compared to the general population. mSome studies suggest that risk is particularly significant in patients with pre-existing metabolic syndrome, and NAFLD can develop within a few years post-surgery. Meta-analyses indicate that cholecystectomy may be an independent risk factor for NAFLD, although the exact causal relationship is still under investigation.

Key words: non-alcoholic fatty liver disease, metabolic syndrome, atherosclerosis.

First page

570

Last page

574

For citation:Khojiev B.B. - CHOLECYSTECTOMY AS A RISK FACTOR FOR NON-ALCOHOLIC FATTY LIVER DISEASE DEVELOPMENT//New Day in Medicine 12(86)2025 570-574 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

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