112 -12 (86) 2025 - Ortikova F., Akhmadzhonova G. - RELATIONSHIP BETWEEN CLINICAL FACTORS AND MORPHOLOGICAL INJURIES TO THE PLACENTA IN PREMATURE ABROAD IN HIGH-RISK PREGNANCY WOMEN

RELATIONSHIP BETWEEN CLINICAL FACTORS AND MORPHOLOGICAL INJURIES TO THE PLACENTA IN PREMATURE ABROAD IN HIGH-RISK PREGNANCY WOMEN

Ortikova F. - Samarkand State Medical University

Akhmadzhonova G. - Andijan State Medical Institute

Resume

Premature abruption of a normally implanted placenta (placental abruption) was investigated as one of the most severe and prognostically unfavorable obstetric conditions in pregnant women. The aim of the study was to evaluate clinical and morphological factors associated with the development of placental abruption in women at high risk. The material included the results of a comprehensive clinico-morphological analysis of 107 women diagnosed with placental abruption at 28–36 weeks of gestation; the control group consisted of women with a physiological course of pregnancy and delivery. Morphological examination of the placentas revealed characteristic changes, including extensive intervillous hemorrhages, trophoblastic destruction with fibrinoid necrosis, as well as signs of vascular spasm and endothelial dystrophy. The findings indicate that placental abruption is a polyetiological process primarily associated with impaired vascular adaptation and structural alterations of placental tissue, highlighting the future relevance of an integrated clinico-morphological approach for early identification of high-risk patients and prevention of obstetric complications.

Keywords: premature placental abruption, risk group, placental morphology, placental insufficiency, ischemia, vascular disorders

First page

610

Last page

615

For citation:Ortikova F., Akhmadzhonova G. - RELATIONSHIP BETWEEN CLINICAL FACTORS AND MORPHOLOGICAL INJURIES TO THE PLACENTA IN PREMATURE ABROAD IN HIGH-RISK PREGNANCY WOMEN//New Day in Medicine 12(86)2025 610-615 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

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