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  • 118 -12 (86) 2025 - Zakirova G.A., Masharipova D.R. - THE SIGNIFICANCE OF THE END1 GENE LYS198ASN POLYMORPHISM IN THE PATHOGENESIS OF CHRONIC HEART FAILURE AND RENAL DYSFUNCTION IN PATIENTS OF UZBEK ETHNICITY

118 -12 (86) 2025 - Zakirova G.A., Masharipova D.R. - THE SIGNIFICANCE OF THE END1 GENE LYS198ASN POLYMORPHISM IN THE PATHOGENESIS OF CHRONIC HEART FAILURE AND RENAL DYSFUNCTION IN PATIENTS OF UZBEK ETHNICITY

THE SIGNIFICANCE OF THE END1 GENE LYS198ASN POLYMORPHISM IN THE PATHOGENESIS OF CHRONIC HEART FAILURE AND RENAL DYSFUNCTION IN PATIENTS OF UZBEK ETHNICITY

Zakirova G.A. - Republican Specialized Scientific - Practical Medical Center of Therapy and Medical Rehabilitation

Masharipova D.R. - Republican Specialized Scientific - Practical Medical Center of Therapy and Medical Rehabilitation

Boboev K.T. - Republican Specialized Scientific and Practical Medical Hematology Center

Resume

Chronic heart failure (CHF) and associated renal dysfunction represent significant medical and social challenges, particularly given the increasing prevalence of cardiovascular disease. Endothelial dysfunction is a key factor in the pathogenesis of CHF. Molecular genetic factors play a significant role in the development of this disease. Recently, particular attention has been paid to the Lys198Asn polymorphism of the endothelin-1 (END1) gene, which controls vascular tone and is involved in fibrosis and inflammation. Studying the clinical significance and prevalence of this polymorphism among Uzbeks with CHF and renal dysfunction allows us to understand the genetic mechanisms of the disease better and help develop personalized methods for early diagnosis and prognosis.

Keywords: renal dysfunction, clinical and humoral aspects, genetic aspects, CHF.

First page

651

Last page

657

For citation:Zakirova G.A., Masharipova D.R., Boboev K.T. - THE SIGNIFICANCE OF THE END1 GENE LYS198ASN POLYMORPHISM IN THE PATHOGENESIS OF CHRONIC HEART FAILURE AND RENAL DYSFUNCTION IN PATIENTS OF UZBEK ETHNICITY//New Day in Medicine 12(86)2025 651-657 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

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