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  • 120 -12 (86) 2025 - Tojiddin K.M., Daniyar A.N. - MORPHOLOGICAL SPECTRUM AND BIOLOGICAL AGGRESSIVENESS OF NEPHROBLASTOMA IN CHILDREN: DATA FROM THE UZBEK POPULATION

120 -12 (86) 2025 - Tojiddin K.M., Daniyar A.N. - MORPHOLOGICAL SPECTRUM AND BIOLOGICAL AGGRESSIVENESS OF NEPHROBLASTOMA IN CHILDREN: DATA FROM THE UZBEK POPULATION

MORPHOLOGICAL SPECTRUM AND BIOLOGICAL AGGRESSIVENESS OF NEPHROBLASTOMA IN CHILDREN: DATA FROM THE UZBEK POPULATION

Tojiddin K.M. - Republic of Specialized Oncology and Radiology, Scientific and Practical Medical Center

Daniyar A.N. - Republic of Specialized Oncology and Radiology, Scientific and Practical Medical Center

Resume

Relevance Nephroblastoma is one of the most common malignant solid tumors in children, characterized by significant morphological heterogeneity and differences in biological behavior. Analysis of national cohorts is important for refining prognostic factors and adapting international guidelines to local practice. Objective: To study the morphological characteristics of nephroblastoma in children in the Uzbek population and their relationship with clinical and radiological parameters determining tumor biological aggressiveness. Materials and Methods: A retrospective and prospective analysis of 230 cases of nephroblastoma diagnosed at the Russian Scientific and Practical Medical Center of Oncology and Radiology (2017–2022) was conducted. Histological subtype, degree of differentiation, stromal profile, tumor size, and invasion using ultrasound, CT, and MRI data were assessed. Statistical analysis included χ² analysis with a significance level of p < 0.05. Results. Classic mixed (45.7%) and blastemal (26.1%) forms predominated. A significant association between age and differentiation was found: G1–G2 (p = 0.0093) predominated in children aged ≤ 3 years, while G3–G4 were more common in patients over 3 years of age. Stromal variants were associated with the tumor's biological potential: fibrous stroma corresponded to favorable forms, while mucoid and necrotic stroma corresponded to aggressive forms. Radiological parameters (large size, invasion of vital structures) significantly correlated with poor differentiation (p = 0.001). Conclusion. The morphological and radiological characteristics of nephroblastoma in the Uzbek population demonstrate a combination of general global patterns and regional characteristics. The identified relationships confirm the importance of early diagnosis and the need to integrate morphological, clinical, and imaging data into personalized treatment algorithms for children with nephroblastoma.

Key words: nephroblastoma, Wilms tumor, pediatric oncology, morphology, stromal profile, degree of differentiation, ultrasound, MSCT, MRI, tumor aggressiveness, Uzbek population.

First page

662

Last page

670

For citation:Tojiddin K.M., Daniyar A.N. - MORPHOLOGICAL SPECTRUM AND BIOLOGICAL AGGRESSIVENESS OF NEPHROBLASTOMA IN CHILDREN: DATA FROM THE UZBEK POPULATION//New Day in Medicine 12(86)2025 662-670 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

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