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  • 133 -12 (86) 2025 - Mukhammedov A.B. - ROC ANALYSIS OF IMMUNOLOGICAL MARKERS IN PREDICTING POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH IHD AFTER CORONARY ARTERY BYPASS GRAFTING

133 -12 (86) 2025 - Mukhammedov A.B. - ROC ANALYSIS OF IMMUNOLOGICAL MARKERS IN PREDICTING POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH IHD AFTER CORONARY ARTERY BYPASS GRAFTING

ROC ANALYSIS OF IMMUNOLOGICAL MARKERS IN PREDICTING POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH IHD AFTER CORONARY ARTERY BYPASS GRAFTING

Mukhammedov A.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Background. Ischemic heart disease is associated with pronounced immune-inflammatory disturbances that significantly contribute to postoperative complications after coronary artery bypass grafting. Objective. To evaluate the prognostic value of immunological markers for postoperative complications in patients with coronary artery disease after CABG using ROC analysis. Materials and Methods. Thirty CAD patients undergoing CABG with cardiopulmonary bypass were analyzed, including 15 patients with postoperative complications; ROC analysis was performed with determination of AUC, cut-off values, sensitivity, and specificity (p<0.05). Results. The highest predictive accuracy was observed for CD4± (AUC=0.733; p=0.029), CD8± (AUC=0.740; p=0.024), IL-6 (AUC=0.740; p=0.024), and IFN-γ (AUC=0.744; p=0.022). Identified cut-off values demonstrated high specificity (up to 100.0%), enabling reliable discrimination of patients at high risk of postoperative complications. Conclusions. Immunological markers demonstrate high prognostic potential for predicting adverse outcomes after CABG. Their combined application improves early risk stratification and postoperative management.

Keywords: coronary artery disease, coronary artery bypass grafting, ROC analysis, immunological markers, postoperative complications.

First page

742

Last page

747

For citation:Mukhammedov A.B. - ROC ANALYSIS OF IMMUNOLOGICAL MARKERS IN PREDICTING POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH IHD AFTER CORONARY ARTERY BYPASS GRAFTING//New Day in Medicine 12(86)2025 742-747 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

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