143 -12 (86) 2025 - Boykulov T.T. - CONSERVATIVE TREATMENT OF URIC ACID KIDNEY STONES

CONSERVATIVE TREATMENT OF URIC ACID KIDNEY STONES

Boykulov T.T. - Teacher of the Department of Morphological Sciences

Resume

The incidence of uric acid stones is steadily increasing, which is explained by their high correlation with obesity, arterial hypertension, metabolic syndrome, diabetes mellitus and aging. The formation of uric acid stones is mainly due to the acidic pH environment of the urine, which is associated with a decrease in the amount of ammonia in the urine as a result of impaired ammonia formation rather than the excretion of soluble urates in the urine. Therefore, urine alkalinization is recommended to prevent uric acid crystallization and is considered an effective treatment. 120 patients with uric acid urolithiasis participated in this study. They were successfully treated with a conservative potassium citrate preparation to dissolve the stones (n = 75) or to prevent stone recurrence (n = 45). The average follow-up period was 3.14 years. Potassium citrate was administered dissolved in 1.5 liters of water, which prevented gastrointestinal discomfort. Complete chemical dissolution (hemolysis) was achieved in 88% of 75 patients with kidney stones at the time of treatment. Risk factors for stone formation decreased during treatment, mainly due to increased diuresis, increased urinary pH, and increased urinary citrate. Treatment was discontinued in only 2% of patients due to side effects. At the same time, despite an increase in the average daily urinary potassium content of 44 mmol/day, no cases of hyperkalemia were recorded. In contrast to data presented in other sources, our study results show that medical treatment of uric acid kidney stones is effective and well tolerated by patients when urine pH is regularly monitored.

Keywords: uric acid, urolithiasis, urinary stone disease, potassium citrate, hyperuricosuria, uremia, nephrolithiasis.

First page

796

Last page

805

For citation:Boykulov T.T. - CONSERVATIVE TREATMENT OF URIC ACID KIDNEY STONES//New Day in Medicine 12(86)2025 796-805 https://newdayworldmedicine.com/en/new_day_medicine/12-86-2025

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