4 -2 (88) 2026 - Akhmedova K.A., Alieva D.A. - COLPOSCOPIC ASSESSMENT OF THE SEVERITY OF PATHOLOGICAL VASCULAR PATTERNS IN CIN I–II: CORRELATION WITH HISTOMORPHOLOGICAL MARKERS OF PROLIFERATION

COLPOSCOPIC ASSESSMENT OF THE SEVERITY OF PATHOLOGICAL VASCULAR PATTERNS IN CIN I–II: CORRELATION WITH HISTOMORPHOLOGICAL MARKERS OF PROLIFERATION

Akhmedova K.A. - Republican Specialized Scientific and Practical Medical Center for Maternal and Child Health (Uzbekistan)

Alieva D.A. - Republican Specialized Scientific and Practical Medical Center for Maternal and Child Health (Uzbekistan)

Resume

This prospective study included 57 patients: 31 with CIN I and 26 with CIN II. All participants underwent extended colposcopy, liquid-based cytology, targeted cervical biopsy, PCR typing of high-risk HPV, and FISH testing for p16/ATM. Follow-up examinations were performed at baseline and at 3, 6, and 12 months.

Keywords: cervical intraepithelial neoplasia, colposcopy, high-risk HPV, acetowhite epithelium, iodine-negative areas, punctuation, mosaic pattern, p16 (FISH), ATM (FISH), HPV persistence.

First page

13

Last page

17

For citation:Akhmedova K.A., Alieva D.A. - COLPOSCOPIC ASSESSMENT OF THE SEVERITY OF PATHOLOGICAL VASCULAR PATTERNS IN CIN I–II: CORRELATION WITH HISTOMORPHOLOGICAL MARKERS OF PROLIFERATION//New Day in Medicine 2(88)2026 13-17 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

  1. Colposcopy and Treatment of Cervical Precancer. IARC Manual for Practitioners. Lyon: International Agency for Research on Cancer, 2017.
  2. Darragh T., Colgan T. The Lower Anogenital Squamous Terminology (LAST) Standardization Project. Arch Pathol Lab Med., 2012;136(10):1266–1297.
  3. Doorbar J. Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci., 2006;110(5):525–541.
  4. Massad L.S. et al. 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors. J Low Genit Tract Dis., 2020;24(2):102–131.
  5. Nayar R., Wilbur D. The Bethesda System for Reporting Cervical Cytology. Springer, 2015.
  6. Sano T., Oyama T. Expression of p16INK4a as a biomarker in cervical intraepithelial neoplasia and invasive carcinoma. Pathology International., 2002;52(10):713–722.
  7. Zannoni G.F. et al. Role of ATM and TP53 alterations in cervical dysplasia progression. Modern Pathology., 2019;32:1544–1552.

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