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  • 5 -2 (88) 2026 - Alieva D.A., Akhmedova K.A. - INNOVATIVE METHODS FOR VISUALIZING CHROMOSOMAL ALTERATIONS IN CERVICAL DYSPLASIA: CAPABILITIES OF LOCUS-SPECIFIC PROBES IN PREDICTING THE COURSE OF CERVICAL NEOPLASIA

5 -2 (88) 2026 - Alieva D.A., Akhmedova K.A. - INNOVATIVE METHODS FOR VISUALIZING CHROMOSOMAL ALTERATIONS IN CERVICAL DYSPLASIA: CAPABILITIES OF LOCUS-SPECIFIC PROBES IN PREDICTING THE COURSE OF CERVICAL NEOPLASIA

INNOVATIVE METHODS FOR VISUALIZING CHROMOSOMAL ALTERATIONS IN CERVICAL DYSPLASIA: CAPABILITIES OF LOCUS-SPECIFIC PROBES IN PREDICTING THE COURSE OF CERVICAL NEOPLASIA

Alieva D.A. - Republican Specialized Scientific and Practical Medical Center for Maternal and Child Health (Uzbekistan)

Akhmedova K.A. - Republican Specialized Scientific and Practical Medical Center for Maternal and Child Health (Uzbekistan)

Resume

The study included 49 patients with cytological signs of atypia: 23 with LSIL/CIN1, 19 with HSIL/CIN2, and 7 with cervical cancer. The diagnostic protocol comprised liquid-based cytology, PCR testing for high-risk HPV (HR-HPV), targeted cervical biopsy, and locus-specific FISH analysis (Ser9, p16, TP53, ATM) performed on liquid-based cytology material. Excisional procedures were performed in patients with CIN2, as well as in CIN1 patients demonstrating FISH-positive chromosomal aberrations. The control group consisted of 10 patients with NILM and a negative HR-HPV test; due to the absence of clinical indications, biopsy was not performed. The distribution of cytological, virological, and molecular-genetic parameters at different grades of cervical intraepithelial neoplasia is presented.

Key words: cervical intraepithelial neoplasia; liquid-based cytology; FISH; chromosomal aberrations; locus-specific probes; biopsy; excisions.

First page

18

Last page

23

For citation:Alieva D.A., Akhmedova K.A. - INNOVATIVE METHODS FOR VISUALIZING CHROMOSOMAL ALTERATIONS IN CERVICAL DYSPLASIA: CAPABILITIES OF LOCUS-SPECIFIC PROBES IN PREDICTING THE COURSE OF CERVICAL NEOPLASIA//New Day in Medicine 2(88)2026 18-23 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

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