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  • 39 -2 (88) 2026 - Mukhitdinova K.O., Aleynik V.A. - CHANGE IN DNA METHYLATION OF LEUKOCYTES IN WOMEN WITH EARLY PREGNANCY AND EXCESSIVE INFLAMMATORY IMMUNE REACTION

39 -2 (88) 2026 - Mukhitdinova K.O., Aleynik V.A. - CHANGE IN DNA METHYLATION OF LEUKOCYTES IN WOMEN WITH EARLY PREGNANCY AND EXCESSIVE INFLAMMATORY IMMUNE REACTION

CHANGE IN DNA METHYLATION OF LEUKOCYTES IN WOMEN WITH EARLY PREGNANCY AND EXCESSIVE INFLAMMATORY IMMUNE REACTION

Mukhitdinova K.O. - Andijan branch of the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan, Andijan State Medical Institute, Tashkent State Medical University

Aleynik V.A. - Andijan branch of the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan, Andijan State Medical Institute, Tashkent State Medical University

Najmutdinova D.K. - Andijan branch of the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan, Andijan State Medical Institute, Tashkent State Medical University

Babich S.M. - Andijan branch of the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan, Andijan State Medical Institute, Tashkent State Medical University

Resume

The study examined changes in leukocyte DNA methylation in women with early pregnancy loss and enhanced pro-inflammatory immune responses. It was found that high activity of pro-inflammatory mechanisms in early pregnancy, in the absence of genital infections and with insufficient compensation by protease inhibitors, creates unfavorable conditions for pregnancy development and increases the risk of spontaneous miscarriage. DNA methylation was also disrupted, as evidenced by a significant increase in DNA methyltransferase 1 (DNMT1) activity and 5-methyl-2′-deoxycytidine levels in leukocytes both before pregnancy and at 6–12 weeks of gestation. Thus, the assessment of pro-inflammatory (TNF-α, IL-1β) and anti-inflammatory (IL-10) cytokines, MMP-9, TIMP-1, as well as DNMT1 activity and 5-methyl-2′-deoxycytidine levels, may serve as informative markers of adverse outcomes in early pregnancy.

Key words: interleukins, protease inhibitors, DNA methyltransferase 1, early pregnancy, miscarriage, epigenetic DNA methylation.

First page

189

Last page

193

For citation:Mukhitdinova K.O., Aleynik V.A., Najmutdinova D.K., Babich S.M. - CHANGE IN DNA METHYLATION OF LEUKOCYTES IN WOMEN WITH EARLY PREGNANCY AND EXCESSIVE INFLAMMATORY IMMUNE REACTION//New Day in Medicine 2(88)2026 189-193 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

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