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  • 42 -2 (88) 2026 - Abdurakhmanova S.I., Ruzmukhammedova S.Sh. - THE ROLE OF HYALURONIC ACID MEDIUM IN INCREASING THE FREQUENCY OF PREGNANCY WITH THE HELP OF ASSISTED REPRODUCTIVE TECHNOLOGIES

42 -2 (88) 2026 - Abdurakhmanova S.I., Ruzmukhammedova S.Sh. - THE ROLE OF HYALURONIC ACID MEDIUM IN INCREASING THE FREQUENCY OF PREGNANCY WITH THE HELP OF ASSISTED REPRODUCTIVE TECHNOLOGIES

THE ROLE OF HYALURONIC ACID MEDIUM IN INCREASING THE FREQUENCY OF PREGNANCY WITH THE HELP OF ASSISTED REPRODUCTIVE TECHNOLOGIES

Abdurakhmanova S.I. - Tashkent State Medical University

Ruzmukhammedova S.Sh. - Tashkent State Medical University

Resume

To enhance the outcomes of assisted reproductive technology (ART), adhesive compounds containing hyaluronic acid are used during embryo transfer in infertile patients. One of the major challenges in ART is that the etiopathogenetic mechanisms of failed embryo implantation are not yet fully understood, which necessitates optimization of both stimulation protocols and methods of patient preparation for embryo transfer. A thorough investigation of the role of hyaluronic acid–containing culture medium in embryo transfer is expected to contribute to improvement in implantation and pregnancy rates, thereby reaffirming the relevance of this topic.

Keywords: assisted reproductive technologies (ART), hyaluronic acid medium, embryo transfer.

First page

203

Last page

207

For citation:Abdurakhmanova S.I., Ruzmukhammedova S.Sh. - THE ROLE OF HYALURONIC ACID MEDIUM IN INCREASING THE FREQUENCY OF PREGNANCY WITH THE HELP OF ASSISTED REPRODUCTIVE TECHNOLOGIES //New Day in Medicine 2(88)2026 203-207 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

  1. Urman et al. (2008) Effect of hyaluronan-enriched transfer medium on implantation and pregnancy rates after day 3 and day 5 embryo transfer: a prospective randomized study. Fert Steril 2008;90(3):604-12.
  2. Bontekoe S et al. (2010) Cochrane Database Syst Rev. 2010 Jul 7;(7):CD007421.
  3. Bontekoe S et al., (2014) Cochrane Database Syst Rev. 2014 Feb 25;2:CD007421.
  4. Balaban B et al. (2011) Effect of hyaluronan-enriched transfer medium on take home baby rate after day 3 and day 5 embryo transfers: a prospective randomized study. Hum Reprod. 2011 July 15(15):i24.
  5. Hashimoto S et al. (2014) EmbryoGlue improvespregnancy and implantation rates: Results from a Metaanalysis on almost 10,000 embryo transfers. Reprod BioMed Online.2014;28(Suppl 1):S7-S8.
  6. Meintjes M (2012) Media composition; macromolecules and embryo growth. Methods Mol Biol. 2012;912:107-27.
  7. Morbeck et al. (2014) Composition of protein supplements used for human embryo culture. J Assist Reprod Genet. 2014;12:1703-11.
  8. Blake et al. (2002) Protein Supplementation of human IVF culture media. J Assist Reprod Genet. 2002;19:137-43.
  9. Leonard et al. (2013) Variability in protein quality used for embryo culture: embryotoxicicity of the stabilizer octanoic acid. Fertil Steril. 2013;100:544-549.
  10. Lane et al. (2003) Cryo-survival and development of bovine blastocysts are enhanced by culture with recombnant albumin and hyaluronan. Mol Reprod Dev 2003;64:70-78.

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