48 -2 (88) 2026 - Agababyan L.R., Elmuradova Ch.A. - MAJOR OBSTETRIC SYNDROMES: RISK FACTORS AND PATHOGENETIC MECHANISMS

MAJOR OBSTETRIC SYNDROMES: RISK FACTORS AND PATHOGENETIC MECHANISMS

Agababyan L.R. - Samarkand State Medical University

Elmuradova Ch.A. - Samarkand State Medical University

Resume

Great obstetric syndromes unite the most clinically significant complications of pregnancy, characterized by multifactorial origin, a long subclinical phase, and placental-fetal involvement. They include preeclampsia, fetal growth restriction, preterm birth/PPROM, fetal demise and gestational diabetes. Current evidence highlights shared pathways: maternal or intrauterine inflammation/infection, impaired uteroplacental perfusion, placental vascular injury, immune maladaptation and prothrombotic shifts. A structured risk-factor assessment (maternal age, metabolic disorders, hypertension, infections, thyroid dysfunction, autoimmune conditions and adverse obstetric history) is essential for prevention and timely surveillance. Improving early prediction tools remains a priority for effective primary prevention.

Keywords: great obstetric syndromes; pregnancy complications; risk factors; inflammation; placental dysfunction; thrombophilia.

First page

237

Last page

241

For citation:Agababyan L.R., Elmuradova Ch.A. - MAJOR OBSTETRIC SYNDROMES: RISK FACTORS AND PATHOGENETIC MECHANISMS//New Day in Medicine 2(88)2026 237-241 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

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