49 -2 (88) 2026 - Nasirova Z.A. - CLINICAL AND MORPHOLOGICAL ANALYSIS OF PLACENTAL–FETAL INTERACTIONS IN WOMEN WITH A HISTORY OF HEAVY MENSTRUAL BLEEDING

CLINICAL AND MORPHOLOGICAL ANALYSIS OF PLACENTAL–FETAL INTERACTIONS IN WOMEN WITH A HISTORY OF HEAVY MENSTRUAL BLEEDING

Nasirova Z.A. - Samarkand State Medical University

Resume

Heavy menstrual bleeding (HMB) is one of the most common causes of anemic syndrome in women of reproductive age, significantly affecting their quality of life, reproductive health, and work capacity. Despite its high prevalence, the problem remains underestimated by both patients and healthcare professionals. HMB is often accompanied by iron deficiency conditions, including latent iron deficiency, which aggravates the course of pregnancy and the postpartum period. The study conducted a retrospective analysis of 144 medical histories of women with HMB, which made it possible to identify the main clinical and demographic features and the frequency of associated complications. The obtained results confirm the need for early diagnosis and prevention of iron deficiency in women with menstrual hypermenorrhea, as well as the importance of a comprehensive approach to managing such patients, including hemostasis assessment, correction of iron deficiency, and individualized therapy selection.

Keywords: heavy menstrual bleeding; iron deficiency anemia; latent iron deficiency; hemostasis; reproductive health; anemic syndrome.

First page

242

Last page

250

For citation:Nasirova Z.A. - CLINICAL AND MORPHOLOGICAL ANALYSIS OF PLACENTAL–FETAL INTERACTIONS IN WOMEN WITH A HISTORY OF HEAVY MENSTRUAL BLEEDING//New Day in Medicine 2(88)2026 242-250 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

  1. Munro M. G. et al. Abnormal uterine bleeding: A well‐travelled path to iron deficiency and anemia //International Journal of Gynecology & Obstetrics. 2020;150(3):275-277.
  2. Myrin–Westesson L. et al. Prevalence of heavy menstrual bleeding, iron deficiency, iron deficiency anemia, and treatment in women with von Willebrand disease—a cohort study //Research and Practice in Thrombosis and Haemostasis. 2025;9(4):102-949.
  3. National Institute of Health and Care Excellence. Heavy menstrual bleeding: assessment and management. NICE guideline. 2018. Last updated: 24 May 2021. Available at: https://www.nice.org.uk/ guidance/ng88/resources/heavy-menstrual-bleeding-assessment-andmanagement-pdf-1837701412549. Accessed: 01.07.2024
  4. Nemeth E. et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein //Blood, The Journal of the American Society of Hematology. 2003;101(7):2461-2463.
  5. Oh C., Keats E. C., Bhutta Z. A. Vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low-and middle-income countries: a systematic review and meta-analysis //Nutrients. 2020;12(2):491.
  6. Obeagu E. I. Prevalence and risk factors of heavy menstrual bleeding in Africa: a narrative review //Annals of Medicine and Surgery. 2025;87(7):4194-4200.
  7. Okafor I. M. et al. Morphological classification of anaemia and neutrophil patterns in pregnant women with asymptomatic malaria parasite infection //Sokoto Journal of Medical Laboratory Science. 2024;9(3):22-31.
  8. Park C. H. et al. Hepcidin, a urinary antimicrobial peptide synthesized in the liver //Journal of biological chemistry. 2001;276(11):7806-7810.
  9. Pattoyevich G. A. Iron deficiency anemia in children: early diagnosis and modern treatment approaches //Web of Medicine: Journal of Medicine, Practice and Nursing. 2025;3(5):494-501.
  10. Pavord S. et al. UK guidelines on the management of iron deficiency in pregnancy //Br J Haematol. – 2020.
  11. Perera C.O., et al. Mild anemia during pregnancy upregulates placental vascularity and VEGF expression // Med Hypotheses. 2016;91:1–4;
  12. Jain V., et al. Angiogenesis in abnormal uterine bleeding: a narrative review // Int J Mol Sci. 2022;23(13):71-89.

    file

    download