35 -1(87) 2026 - Abdulazizkhozhiev B.R., Aleinik V.A. - CHANGES IN STERILE INFLAMMATION AND IMMUNOLOGICAL PARAMETERS IN HEPATITIS C

CHANGES IN STERILE INFLAMMATION AND IMMUNOLOGICAL PARAMETERS IN HEPATITIS C

Abdulazizkhozhiev B.R. - Andijan State Medical Institute, Center for Immunology, Allergology and Human Genomics. ... Address: Andijan region

Aleinik V.A. - Andijan State Medical Institute, Center for Immunology, Allergology and Human Genomics. ... Address: Andijan region

Zhuraeva M.A. - Andijan State Medical Institute, Center for Immunology, Allergology and Human Genomics. ... Address: Andijan region

Babich S.M. - Andijan State Medical Institute, Center for Immunology, Allergology and Human Genomics. ... Address: Andijan region

Resume

The work studied changes in sterile inflammation and immunological parameters in hepatitis C. It was concluded that sterile inflammation is a key driver of HCV progression. In chronic HCV infection, a significant increase in ALT/AST and bilirubin indicates massive cytolysis of hepatocytes and leads to the release of DAMPs (alarmins). These molecules activate TLR4, NLRP3 inflammasome and maintain proinflammatory cascade (TNF-α, IL-1β), even in the absence of active viral replication. Cytokine imbalance occurs due to the dominance of proinflammatory mediators in chronic infection and disrupts the regulation of the immune response. At the same time, serological decrease in Anti-HCVcoreIgG with an increase in Anti-HCVcoreIgM and Anti-HCVNS4/NS5 reflects immune exhaustion and viral persistence. Significantly high viral load confirms active replication, but part of the inflammation is due to DAMPs (sterile component). In HCV postinfection, persistence of viral components (e.g. core protein) and residual DAMPs provoke weak but chronic inflammation due to TNF-α, IL-1β. Moderate hyperbilirubinemia and elevated ALT/AST may be associated with initiated DAMPs (e.g., HMGB1 activates hepatic stellate cells). Low viral load does not exclude persistence of non-replicative forms of HCV that support low-grade inflammation via TLR signaling.

Keywords: sterile inflammation, proinflammatory immune response, interleukins, liver function tests, alarmins, hepatitis C.

First page

196

Last page

202

For citation:Abdulazizkhozhiev B.R., Aleinik V.A., Zhuraeva M.A., Babich S.M. - CHANGES IN STERILE INFLAMMATION AND IMMUNOLOGICAL PARAMETERS IN HEPATITIS C//New Day in Medicine 1(87)2026 196-202 https://newdayworldmedicine.com/en/new_day_medicine/1-87-2026

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