53 -2 (88) 2026 - Yakubova S.N. - PATHOLOGICAL CHANGES IN THE CHORION IN HYPERHOMOCYSTEINEMIA

PATHOLOGICAL CHANGES IN THE CHORION IN HYPERHOMOCYSTEINEMIA

Yakubova S.N. - Andijan State Medical Institute

Resume

This article studies pathomorphological changes in the chorion in the 3rd month of pregnancy in conditions of gypergomocysteinemia. Gypergomocysteinemia is a multifactorial condition requiring a comprehensive approach. The amino acid gomocysteine is a natural sulfur-containing amino acid that is not found in proteins. Chorionl tissue biopsy material - embryonic, extraembryonic structures, and their intermediate tissues - from 40 fetuses who underwent medical abortion at the 12th week of gestation was studied. When pathologically examining surgical biopsy materials, it was observed that various changes in the chorion during the first trimester of fetal development lead to the development of fetochorionl insufficiency, various gestational complications, impaired differentiation of the chorionl angiovasculogenesis, and slowed growth. In gypergomocysteinemia, the following changes were detected in the chorionl - embryonic, extraembryonic structures, their intermediate tissues, namely, without signs of active formation of vessels of the chorionic villi, slowing down of differentiation and growth of the chorionic epithelium, lagging behind in vasculo- and angiogenesis, the occurrence of dystrophic and necrobiotic changes in the chorionic epithelium and stroma, edema of the villi, focal destidal lymphocytic infiltration, focal deposition of fibrinoid, microthrombi, focal necrosis of destidal cells, fragmentation of the chorionic villi, focal and extensive hemorrhages were observed.

Keywords: gomocysteine, gomocysteinemia, pregnancy, fetus, chorion, embryonic, extraembryonic structures.

First page

267

Last page

271

For citation:Yakubova S.N. - PATHOLOGICAL CHANGES IN THE CHORION IN HYPERHOMOCYSTEINEMIA//New Day in Medicine 2(88)2026 267-271 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

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