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  • 46 -1 (87) 2026 - Kholikov A.Y., Abdrakhimov A.R. - CENTRAL HEMODYNAMICS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ON HEMODIALYSIS

46 -1 (87) 2026 - Kholikov A.Y., Abdrakhimov A.R. - CENTRAL HEMODYNAMICS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ON HEMODIALYSIS

CENTRAL HEMODYNAMICS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ON HEMODIALYSIS

Kholikov A.Y. - Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y. Kh. Turakulov, Specialized Hospital

Abdrakhimov A.R. - Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y.Kh. Turakulov, Ministry of Health of the Republic of Uzbekistan

Kodirova R.R. - Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y. Kh. Turakulov, Specialized Hospital

Resume

The aim of the study was to investigate the risk factors for intradialytic hypotension and cardiovascular complications in patients with type 2 diabetes mellitus receiving program hemodialysis. Material and methods. We examined and surveyed 55 patients with type 2 diabetes mellitus and end-stage chronic kidney disease. Of these, there were 18 women and 37 men. The average age of men was 56.7 ± 4.2 years, and the average age of women was 53.6 ± 4.8 years. The control group consisted of 20 patients with type 2 diabetes mellitus and without CKD of the corresponding age. Patients were divided into 3 groups according to glycemic variability: Group A (low glycemic variability), n=15, Group B (moderate variability), n=23, Group C (high variability), n=17. All 55 patients underwent all examinations, including general clinical, biochemical, hormonal blood tests in the research laboratory of the Fergana branch of the Republican Scientific and Practical Medical Center of Endocrinology of the Ministry of Health of the Republic of Uzbekistan, as well as ECG, echo-ECG, ultrasound of internal organs, consultation with a cardiologist, neurologist, nephrologist, ophthalmologist, surgeon, and other studies. Glycemic variability was assessed in all patients (according to CGM data). Study results. The majority of concomitant pathologies were observed in group 1 of patients - 43 diseases, in group 2 - 42 and in group 3 - 27. Cardiovascular diseases (hypertension, coronary heart disease, heart failure and arrhythmia) as a comorbid pathology were observed in 60% of patients with type 2 diabetes on hemodialysis. A reliable difference in the central hemodynamic parameters of groups 2 and 3 compared with the control group is noted: LV EDD, ESV, EDV, LV ESR (p < 0.05), mean pulmonary artery pressure, early diastolic filling time, LVEFT (p < 0.001), EF, peak E and A wave velocity ratio, LV isovolumic relaxation time, LVM, LVMI (p < 0.05), while in group 1 all echo-ECG parameters were almost within the normal range. Conclusions: 1. The highest score on the CHF assessment scale was scored by patients of group 1 – 13 points (IV FC CHF), in 2nd place were patients of group 2 – 9 points (III FC –CHF) and in 3rd place were patients of group 3 – 1 point. 2. In the group of patients with type 2 diabetes mellitus and stage 5 CKD, we identified changes in echo-ECG according to the type of diastolic dysfunction of the left ventricle of 1-2 degrees with a tendency to increase the mean pressure in the pulmonary artery.

Key words: diabetes mellitus 2, CKD, hemodialysis, echo-ECG

First page

261

Last page

267

For citation:Kholikov A.Y., Abdrakhimov A.R., Kodirova R.R. - CENTRAL HEMODYNAMICS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ON HEMODIALYSIS//New Day in Medicine 1(87)2026 261-267 https://newdayworldmedicine.com/en/new_day_medicine/1-87-2026

List of References

  1. Scandiffio T, Veglia L, Dagostino F, Casino F, Guerricchio G. Il ventricolo sinistro nei nefropatici cronici. Studio ecocardiografico e poligrafico prima e dopo trattamento dialitico [The left ventricle in chronic renal failure patients. Ecocardiographic and poligraphic study before and after hemodialysis (author's transl)]. G Ital Cardiol. 1979;9(7):729-33.
  2. Cornacchiari M, Mudoni A, Borin F, Stasi A, Ponticelli MG, Visciano B, Guastoni C. [Evaluation via ecocolordoppler before creating a vascular access for hemodyalisis: a monocentric experience]. G Ital Nefrol. 2020 Jun 10;37(3):2020-vol3.
  3. Akmal M. Hemodialysis in diabetic patients. Am J Kidney Dis. 2001 Oct;38(4 Suppl 1):S195-9. doi: 10.1053/ajkd.2001.27443.
  4. Joki N, Hase H, Ishikawa H, Fukazawa C, Nakamura R, Imamura Y, Tanaka Y, Saijyo T, Fukazawa M, Yamaguchi T. Coronary artery disease as a definitive risk factor of short-term outcome after starting hemodialysis in diabetic renal failure patients. Clin Nephrol. 2001 Feb; 55(2):109-14.
  5. Баланов Ю. А. Конради А. О., Концевая А. В., Ротарь О. П. Основные классификации и шкалы риска в кардиологии. Общероссийская общественная организация // «Содействия профилактике и лечению артериальной гипертензии „Антигипертензивная Лига”», 2020; 19 стр.
  6. Janani Rangaswami 1, Roy O Mathew 2Pathophysiological Mechanisms in Cardiorenal Syndrome // Adv Chronic Kidney Dis. 2018 Sep;25(5):400-407. doi: 10.1053/j.ackd.2018.08.006.
  7. Ronco C., McCullough P., Anker S.D., Anand I., Aspromonte N., Bagshaw S.M., Bellomo R., Berl T., Bobek I., Cruz D.N., et al. Cardio-Renal Syndromes: Report from the Consensus Conference of the Acute Dialysis Quality Initiative. Eur. Heart J. 2009;31:703–711. doi: 10.1093/eurheartj/ehp507
  8. Alberto Palazzuoli 1, Gaetano Ruocco 2Heart-Kidney Interactions in Cardiorenal Syndrome Type 1// Adv Chronic Kidney Dis. 2018 Sep;25(5):408-417. doi: 10.1053/j.ackd.2018.08.013.
  9. Nicholas Wettersten 1, Alan S Maisel 1, Dinna N Cruz 2Toward Precision Medicine in the Cardiorenal Syndrome //Adv Chronic Kidney Dis. 2018 Sep;25(5):418-424.doi: 10.1053/j.ackd.2018.08.017.
  10. Thomas A Mavrakanas , Aisha Khattak , Karandeep Singh , David M Charytan. Epidemiology and Natural History of the Cardiorenal Syndromes in a Cohort with Echocardiography // Clin J Am Soc Nephrol. 2017 Oct 6;12(10):1624-1633. doi: 10.2215/CJN.04020417. Epub 2017 Aug 11.
  11. Beatriz Delgado-Valero 1, Victoria Cachofeiro 1 2, Ernesto Martínez-Martínez 1 2Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved //Cells. 2021 Jul 19;10(7):1824. doi: 10.3390/cells10071824.

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