49 -1 (87) 2026 - Sarboyev E.R. - CLINICAL AND LABORATORY FEATURES OF DENTAL IMPLANT OSSEOINTEGRATION IN PATIENTS WITH RHEUMATOID ARTHRITIS: A PROSPECTIVE COMPARATIVE STUDY

CLINICAL AND LABORATORY FEATURES OF DENTAL IMPLANT OSSEOINTEGRATION IN PATIENTS WITH RHEUMATOID ARTHRITIS: A PROSPECTIVE COMPARATIVE STUDY

Sarboyev E.R. - Tashkent State Medical University

Resume

Rheumatoid arthritis is a chronic autoimmune disease characterized by systemic inflammation and impaired bone metabolism, which may adversely affect the osseointegration of dental implants. This prospective comparative study (2023–2025, n=80) aimed to evaluate clinical, laboratory, and radiological factors influencing dental implant osseointegration in patients with rheumatoid arthritis. The study included patients with rheumatoid arthritis who underwent dental implantation (n=28), systemically healthy individuals with dental implants (n=27), and patients with rheumatoid arthritis without implant treatment (n=25). Bone tissue status was assessed using dual-energy X-ray absorptiometry and cone-beam computed tomography with measurement of alveolar bone density in Hounsfield units; systemic inflammatory markers (CRP, ESR) and cytokines (IL-6, IL-10, TNF-α) were additionally evaluated. Patients with rheumatoid arthritis demonstrated a statistically significant reduction in bone mineral density and alveolar bone density compared with the control group (p<0.05). A strong positive correlation was found between bone density and primary implant stability parameters (r=0.68; p<0.001). An alveolar bone density threshold of ≥678 HU was associated with a favorable prognosis for osseointegration. The overall success rate of dental implantation in patients with rheumatoid arthritis was 96.7%, comparable to that in healthy individuals. A comprehensive diagnostic algorithm incorporating clinical and laboratory assessment of disease activity and CBCT-based evaluation of alveolar bone density was proposed, improving the safety and predictability of implant treatment in patients with rheumatoid arthritis.

Keywords: rheumatoid arthritis, dental implantation, osseointegration, bone mineral density, CBCT, cytokines, ISQ.

First page

283

Last page

289

For citation:Sarboyev E.R. - CLINICAL AND LABORATORY FEATURES OF DENTAL IMPLANT OSSEOINTEGRATION IN PATIENTS WITH RHEUMATOID ARTHRITIS: A PROSPECTIVE COMPARATIVE STUDY//New Day in Medicine 1(87)2026 283-289 https://newdayworldmedicine.com/en/new_day_medicine/1-87-2026

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