62 -1 (87) 2026 - Ro`ziqulova F.U., Yariyev A.A. - PHYSIOLOGICAL ASSESSMENT OF THE ACUTE STRESS RESPONSE IN RATS WITH ANALYSIS OF ADRENALINE LEVELS AND BODY WEIGHT DYNAMICS

PHYSIOLOGICAL ASSESSMENT OF THE ACUTE STRESS RESPONSE IN RATS WITH ANALYSIS OF ADRENALINE LEVELS AND BODY WEIGHT DYNAMICS

Ro`ziqulova F.U. - Termez Branch of Tashkent State Medical University, Republican Scientific Center for Emergency Medical Care, Syrdarya Branch, Gulistan

Yariyev A.A. - Termez Branch of Tashkent State Medical University, Republican Scientific Center for Emergency Medical Care, Syrdarya Branch, Gulistan

Axmedov K.H. - Termez Branch of Tashkent State Medical University, Republican Scientific Center for Emergency Medical Care, Syrdarya Branch, Gulistan

Resume

This experimental study evaluated physiological responses to acute stress in rats using a forced swim model. Thirty rats were divided into control and stress groups. Adrenaline levels and body weight were assessed on day four of exposure. Stressed animals showed a significant increase in plasma adrenaline and a decrease in body weight compared to controls, indicating activation of the sympatho-adrenal system and metabolic shifts. The model proved effective for studying acute stress-related neuroendocrine and metabolic responses.

Keywords: General Adaptation Syndrome, acute stress, experimental study, body weight, adrenaline.

First page

367

Last page

370

For citation:Ro`ziqulova F.U., Yariyev A.A., Axmedov K.H. - PHYSIOLOGICAL ASSESSMENT OF THE ACUTE STRESS RESPONSE IN RATS WITH ANALYSIS OF ADRENALINE LEVELS AND BODY WEIGHT DYNAMICS//New Day in Medicine 1(87)2026 367-370 https://newdayworldmedicine.com/en/new_day_medicine/1-87-2026

List of References

1. Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ / [под общ. ред. Р. У. Хабриева]. – 2-е изд., перераб. и доп. – М.: ОАО Изд-во «Медицина», 2005. – 832 с.
2. Руководство по проведению доклинических исследований лекарственных средств. Часть первая / [под ред. А.Н. Миронова]. – М.: Гриф и К, 2012. – 944 с.
3. Alam MJ, et al. Prevalence and level of stress among final-year students at a health science institute in Bangladesh. 2025. (≈68.6 % студентов испытывали стресс)
4. Bezie AE, et al. Prevalence of stress and associated factors among students. Front Public Health. 2025 (≈37–40 % стресс-симптомов у студентов)
5. Dülger H., et al. Prevalence of stress, anxiety, depression and sleep issues. PMC. 2025 (≈39 % стресс)
6. Roth RR. General adaptation syndrome (GAS). EBSCOhost Research Starters. 2025 (объяснение GAS модели и её значимости)
7. Rosas-Sánchez, G. U., German-Ponciano, L. J., Rodríguez-Landa, J. F. (2022). Considerations of pool dimensions in the forced swim test in predicting the potential antidepressant activity of drugs. Frontiers in Behavioral Neuroscience, 15, 757348. https://doi.org/10.3389/fnbeh.2021.757348
8. Sokal, R. R., Rohlf, F. J. (2012). Biometry: The Principles and Practice of Statistics in Biological Research (4th ed.). W. H. Freeman.
9. Tshomo T., et al. Prevalence and factors associated with workplace stress. 2025 (48.2 % с рабочим стрессом)
10. Yang, L., Xu, B., Yuan, C., Dai, Z., Wang, Y., Li, Q., Yang, Q., Li, N., Qing, H. (2019). The antioxidative action of ZTP by increasing Nrf2/ARE signal pathway. Evidence-Based Complementary and Alternative Medicine, 2019, Article 5421528.

    file

    download