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  • 64 -1 (87) 2026 - Qilicheva V.A. - CLINICAL AND BIOCHEMICAL PROFILE OF FOLLICULAR FLUID AS A PREDICTOR OF OOCYTE QUALITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

64 -1 (87) 2026 - Qilicheva V.A. - CLINICAL AND BIOCHEMICAL PROFILE OF FOLLICULAR FLUID AS A PREDICTOR OF OOCYTE QUALITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

CLINICAL AND BIOCHEMICAL PROFILE OF FOLLICULAR FLUID AS A PREDICTOR OF OOCYTE QUALITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

Qilicheva V.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age and represents a leading cause of anovulatory infertility. Despite the widespread use of assisted reproductive technologies (ART), particularly in vitro fertilization (IVF), treatment outcomes in women with PCOS remain highly variable, largely due to impaired folliculogenesis and reduced oocyte quality. Therefore, the identification of reliable biomarkers reflecting the functional competence of oocytes is of considerable clinical relevance. This study aimed to investigate the hormonal and biochemical characteristics of follicular fluid in women with polycystic ovary syndrome and to evaluate their association with oocyte quality and IVF outcomes. A comparative analysis was performed between patients with PCOS and women without endocrine disorders undergoing IVF treatment. Concentrations of anti-Müllerian hormone (AMH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), as well as oxidative stress markers, including malondialdehyde (MDA) and total antioxidant capacity (TAC), were assessed in follicular fluid samples. The results demonstrated that women with PCOS exhibited significantly higher levels of AMH and oxidative stress markers in follicular fluid, accompanied by reduced antioxidant activity, compared to the control group. Significant correlations were identified between the hormonal and biochemical composition of follicular fluid and oocyte morphological and functional quality, as well as fertilization and embryo development rates. These findings highlight the pivotal role of the follicular microenvironment in determining oocyte developmental competence in women with PCOS. Comprehensive evaluation of hormonal and oxidative-antioxidant parameters of follicular fluid may serve as a valuable prognostic tool for optimizing IVF outcomes and individualizing therapeutic strategies in patients with polycystic ovary syndrome.

Keywords: polycystic ovary syndrome; follicular fluid; oocyte quality; anti-Müllerian hormone; oxidative stress; antioxidant capacity; in vitro fertilization

First page

376

Last page

380

For citation:Qilicheva V.A. - CLINICAL AND BIOCHEMICAL PROFILE OF FOLLICULAR FLUID AS A PREDICTOR OF OOCYTE QUALITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME//New Day in Medicine 1(87)2026 376-380 https://newdayworldmedicine.com/en/new_day_medicine/1-87-2026

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