66 -1 (87) 2026 - Khudoyberdiyeva G.S., Kasparova G.A. - OPIOID-SPARING ANALGESIA AND DEXMEDETOMIDINE SEDATION DURING CESAREAN SECTION UNDER SPINAL ANESTHESIA

OPIOID-SPARING ANALGESIA AND DEXMEDETOMIDINE SEDATION DURING CESAREAN SECTION UNDER SPINAL ANESTHESIA

Khudoyberdiyeva G.S. - Samarkand State Medical University

Kasparova G.A. - Samarkand State Medical University

Resume

The aim of this study was to optimize the efficacy of dexmedetomidine (DEX)-based medication sedation on the background of spinal anesthesia (SA) in pregnant women undergoing cesarean section (CS) and to evaluate its impact on postoperative cognitive dysfunction (POCD). The study included 200 women at risk of POCD who underwent elective CS between 2021 and 2024. Patients were divided into a main group (n=100, DEX sedation without opioids) and a control group (n=100, sedation with ketamine, propofol, diazepam, or sodium oxybutyrate). Hemodynamics, respiration, psychoemotional status (RASS, BIS, MMSE, MoCA-test), and neonatal condition (Apgar, NACS) were assessed. DEX provided light-to-moderate sedation in 95% of cases without POCD development in 98%, reduced maternal and fetal complications, and minimized impact on neonatal vital systems (86% without depression). DEX demonstrated a pronounced opioid-sparing effect. An optimal regimen was developed: bolus 1 μg/kg followed by infusion 0.5–1 μg/kg/h. DEX is a safe and effective agent for opioid-sparing analgesia and sedation in CS, preventing POCD and improving perinatal outcomes.

Keywords: Dexmedetomidine, spinal anesthesia, cesarean section, sedation, opioid-sparing analgesia, postoperative cognitive dysfunction.

First page

386

Last page

391

For citation:Khudoyberdiyeva G.S., Kasparova G.A. - OPIOID-SPARING ANALGESIA AND DEXMEDETOMIDINE SEDATION DURING CESAREAN SECTION UNDER SPINAL ANESTHESIA//New Day in Medicine 1(87)2026 386-391 https://newdayworldmedicine.com/en/new_day_medicine/1-87-2026

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