69 -2 (88) 2026 - Nazarova Z.Yu., Akhmedov F.K. - RISK OF ENDOMETRITIS AND INTERPRETATION OF TNF-Α IN WOMEN COMPLICATED BY ENDOMETRITIS

RISK OF ENDOMETRITIS AND INTERPRETATION OF TNF-Α IN WOMEN COMPLICATED BY ENDOMETRITIS

Nazarova Z.Yu. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Akhmedov F.K. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Karimova N.N. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Resume

Purpose of the research. Studying the role of TNF-α in women at risk of endometritis and complicated endometritis. Studies have shown that the prolonged presence of opportunistic microorganisms in the uterine cavity is the cause of abnormal immune reactions. This causes a local inflammatory process, leading to an increase in the number of anti-inflammatory cytokines in the endometrium, including tumor necrosis factor-α (TNF-α), which, in turn, leads to a disruption of endometrial development.

Keywords: Endometritis, tumor necrosis factor alpha, cytokines, edometrial layer

First page

346

Last page

350

For citation:Nazarova Z.Yu., Akhmedov F.K., Karimova N.N. - RISK OF ENDOMETRITIS AND INTERPRETATION OF TNF-Α IN WOMEN COMPLICATED BY ENDOMETRITIS//New Day in Medicine 2(88)2026 346-350 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

1. Силькина Марина Олеговна, Соснова Елена Алексеевна Хронический эндометрит и его влияние на репродуктивную функцию женщины // Архив акушерства и гинекологии им. В. Ф. Снегирева. 2020;3:120-123.
2. Бодашевская, КД, Суханова, АА, Таран, О. А., Ластовецкая, О. Б., Боднарчук, ОВ, Белинский, АВ, Вознюк, АВ (2024). Оценка факторов риска хронического эндометрита после раннего искусственного аборта. В Украинском журнале перинатологии и педиатрии 2024;3(99):61–66.
3. Кобаидзе Е.Г. Хронический эндометрит у пациенток репродуктивного возраста: возможности индивидуализированной терапии. Акушерство, Гинекология и Репродукция. 2020;14(3):283-295.
4. Кобаидзе Е. Г. Особенности влагалищной и кишечной микрофлоры у больных с хроническим эндометритом в контексте исследования клеточного иммунитета. Российский вестник акушера-гинеколога. 2019;19(1):80–5.
5. Resta L, Loizzi V, Pinto V, Santarsiero C, Cicinelli R, Greco P, et al. Antibiotic therapy versus no treatment for chronic endometritis: a case-control study. Fertil Steril. 2021;115:1541-8. doi: 10.1016/j.fertnstert.2021.01.018
6. Inversetti A, Marraffa S, Campagnolo L, Arthur J, Zambella E, Di Simone N., et al. Chronic endometritis and recurrent reproductive failure: a systematic review and meta-analysis. Front Immunol. 2024;15:1427454.
7. Zhu Y, Li H, He F, Liu S, Yang X, Wang L, et al. Recombinant humanized collagen remodels endometrial immune microenvironment of chronic endometritis through macrophage immunomodulation. Regener Biomater. 2023;10:33. doi: 10.1093/rb/rbad033
8. Alonso L, Laganà AS, Ghezzi F, Casarin J, and Carugno J. Chronic endometritis: old problem, novel insights and future challenges. Int J Fertil Steril. 2020;13:250–6.
9. Liu Q, Wang X, Li T, Li H, Li G, Tan L, et al. Deciphering the role of female reproductive tract microbiome in reproductive health: a review. Front Cell Infect Microbiol. (2024) 14:1351540.
10. Hojjati R, Komorowski A, Maniar K, Pavone ME, Bakkensen J, Bernardi L., et al. Chronic endometritis: screening, treatment, and pregnancy outcomes in an academic fertility center. J Assist Reprod Genet. 2023;40:2463-71.

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