78 -2 (88) 2026 - Orazmuradov A.A. Khusainova D.M. - THE IMPACT OF OBESITY AND ANEMIA ON THE RISK OF LATE REPRODUCTIVE LOSS

THE IMPACT OF OBESITY AND ANEMIA ON THE RISK OF LATE REPRODUCTIVE LOSS

Orazmuradov A.A. - Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia named after Patrice Lumumba"

Khusainova D.M. - Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia named after Patrice Lumumba"

Mukovnikova E.V. - Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia named after Patrice Lumumba"

Bekbaeva I.V. - Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia named after Patrice Lumumba"

Egimbayev K., - Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia named after Patrice Lumumba"

Adan Z.A. - Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia named after Patrice Lumumba"

Orazmuradova G.A. - Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia named after Patrice Lumumba"

Resume

Obesity and anemia are common extragenital diseases in women of reproductive age, which significantly increase the risk of adverse pregnancy outcomes, including late spontaneous miscarriages. A retrospective study included 94 women with late reproductive losses (12–22 weeks of gestation). Participants were grouped according to obesity (BMI ≥30 kg/m²) and anemia (hemoglobin <110 g/L). Complete blood count (RBC, WBC platelets) and coagulation parameters (aPTT, fibrinogen) were assessed. Women with obesity showed increased RBC, platelets, and fibrinogen levels (p<0.05). In women with anemia, RBC levels were decreased and aPTT was prolonged (p<0.01), while differences in platelets, WBC, and fibrinogen were not significant. Gestational age significantly influenced hemoglobin levels (p=0.007). These findings highlight the importance of considering obesity and anemia in monitoring women with late reproductive losses to optimize clinical management and prevent complications.

Key words: Late reproductive losses, anemia, obesity, body mass index, coagulation profile, laboratory parameters.

First page

392

Last page

399

For citation:Orazmuradov A.A. Khusainova D.M., Mukovnikova E.V., Bekbaeva I.V., Egimbayev K., Adan Z.A., Orazmuradova G.A. - THE IMPACT OF OBESITY AND ANEMIA ON THE RISK OF LATE REPRODUCTIVE LOSS//New Day in Medicine 2(88)2026 392-399 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

  1. Azzam A, Khaled H, Alrefaey AK, Basil A, Ibrahim S, Elsayed MS, Khattab M, Nabil N, Abdalwanees E, Halim HWA. Anemia in pregnancy: a systematic review and meta-analysis of prevalence, determinants, and health impacts // BMC Pregnancy and Childbirth. 2025;25:29. DOI: 10.1186/s12884-024-07111-9.
  2. Barbouni K, Jotautis V, Metallinou D, Diamanti A, Orovou E, Liepinaitienė A, Nikolaidis P, Karampas G, Sarantaki A. When weight matters: how obesity impacts reproductive health and pregnancy — a systematic review // Current Obesity Reports. 2025;14:37. DOI: 10.1007/s13679-025-00629-9.
  3. Boxem Aline J., Blaauwendraad Sophia M., Mulders Annemarie G.M.G.J., Bekkers Eline L., Kruithof Claudia J., Steegers Eric A.P., Gaillard Romy, Jaddoe Vincent W.V. Preconception and early‑pregnancy body mass index in women and men, time to pregnancy, and risk of miscarriage // JAMA Network Open. 2024;7(9): e2436157. DOI: 10.1001/jamanetworkopen.2024.36157.
  4. McLean S., Boots C.E. Obesity and miscarriage // Seminars in Reproductive Medicine. 2023;41(3‑4):80-86. DOI: 10.1055/s-0043-1777759. — PMID: 38101448.
  5. Marinelli S., Napoletano G., Straccamore M., Basile G. Female obesity and infertility: outcomes and regulatory guidance // Acta Biomedica. 2022;93(4):e2022278. DOI: 10.23750/abm.v93i4.13466. — PMID: 36043953.
  6. Shi H, Chen L, Wang Y, Sun M, Guo Y, Ma S, Wang X, Jiang H, Wang X, Lu J, Ge L, Dong S, Zhuang Y, Zhao Y, Wei Y, Ma X, Qiao J. Severity of anemia during pregnancy and adverse maternal and fetal outcomes // JAMA Network Open. 2022;5(2):e2147046. DOI: 10.1001/jamanetworkopen.2021.47046.
  7. Succurro E., Vitacolonna E. Editorial: obesity, hyperglycemia, and pregnancy: from pathophysiology to clinical practice — volume II // Frontiers in Endocrinology (Lausanne). — 2023;14:1283609. DOI: 10.3389/fendo.2023.1283609. — PMID: 37766677.
  8. Wang R, Xu S, Hao X, Jin X, Pan D, Xia H, Liao W, Yang L, Wang S. Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies // Frontiers in Global Women’s Health. 2025. DOI: 10.3389/fgwh.2025.1502585.
  9. World Obesity Federation. World Obesity Atlas 2024 [Electronic resource]. — London: World Obesity Federation, 2024. URL: https://data.worldobesity.org/publications/WOF-Obesity-Atlas-v7.pdf (accessed 25.08.2025).
  10. Zheng L, Yang L, Guo Z, Yao N, Zhang S, Pu P. Obesity and its impact on female reproductive health: unraveling the connections // Frontiers in Endocrinology. 2024;14:1326546. DOI: 10.3389/fendo.2023.1326546.

    file

    download