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  • 100 -2 (88) 2026 - Najmetdinova D.F., Negmatullaeva M.N. - PREDICTIVE MARKERS OF PREECLAMPSIA LAYERING IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION

100 -2 (88) 2026 - Najmetdinova D.F., Negmatullaeva M.N. - PREDICTIVE MARKERS OF PREECLAMPSIA LAYERING IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION

PREDICTIVE MARKERS OF PREECLAMPSIA LAYERING IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION

Najmetdinova D.F.- Bukhara State Medical Institute named after Abu Ali ibn Sina

Negmatullaeva M.N. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Purpose of the study: Optimization of pregnancy management tactics in women with chronic arterial hypertension, based on the identification of hemodynamic, clinical, and laboratory markers for early preclinical diagnosis of preeclampsia layering. Materials and methods of research: The studies were conducted starting from the first trimester of pregnancy on a contingent of 100 women with anamnestic data on the risk of developing PE. In all women, indicators of systemic hemodynamics, central hemodynamics, and regional analysis using the Doppler method were studied; a clinic for biochemical research was utilized, and glomerular filtration rate indicators were calculated. Results of the study: The blood flow in the renal artery of the SD was 2.62, which was 18.5% more than in the control group. Respectively, impaired renal blood flow affected the parameters of clinical and laboratory data. Cystatin-C increased to 1.05 ± 0.30 compared with the data of the control group (0.55 ± 0.15), an increase of 52.3%. When comparing three markers of GFR (urea, creatinine, and cystatin), Cystatin-C showed diagnostic value as a marker predicting impaired renal function due to a decrease in glomerular filtration rate, which was associated with impaired organ blood flow in the renal vessels. Therefore, serum cystatin-C closely reflects the functional changes in the kidneys, which lead to an increase in blood pressure and urinary albumin excretion as a marker of the stage of transition from CAH to preeclampsia.

Key words: Chronic hypertension, pregnancy, Cystatin-C, preeclampsia.

First page

522

Last page

529

For citation:Najmetdinova D.F., Negmatullaeva M.N. - PREDICTIVE MARKERS OF PREECLAMPSIA LAYERING IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION//New Day in Medicine 2(88)2026 522-529 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

  1. Ахмедов Ф.К., Негматуллаева М.Н. Особенности течения беременности и риск неблагоприятных исходов в зависимости от степени тяжести преэклампсии. Доктор Ахборотномаси. 2022;2.1(103):40–43.
  2. Балушкина А.А., Тютюнник В.Л., Кан Н.Е., Харченко Д.К., Борис Д.А. Прогнозирование и лабораторная диагностика гипертензивных расстройств при беременности. РМЖ. Мать и дитя. 2019;2(2):89–94. DOI:10.32364/2618-8430-2019-2-2-89-94.
  3. Можинская Ю.В., Белик С.Н., Подгорный И.В., Евдокимова Е.Г. Особенности маточно-плацентарной гемодинамики и структурно-функциональных изменений в системе «мать–плацента–плод» при гипертонической болезни. Молодой ученый. 2016;18.1(122.1):60–62. Available from: https://moluch.ru/archive/122/33735
  4. Никитаева А.П., Росюк Е.А., Вишнева Е.М. Влияние гестационной артериальной гипертензии на течение беременности и развитие осложнений со стороны матери и плода. Современные проблемы науки и образования. 2023;(4). Available from: https://science-education.ru/ru/article/view?id=32862
  5. Негматуллаева М.Н., Ахмедов Ф.К. Особенности почечного кровотока и динамика концентрации мочевой кислоты у женщин при беременности, осложнённой преэклампсией. Клиническая нефрология. 2018;(1):38–40.
  6. Чулков В.С., Сюндюкова Е.Г., Чулков Вл.С., Тарасова О.А., Романюго Г.Д. Гипертензивные нарушения во время беременности и риск сердечно-сосудистых заболеваний. Профилактическая медицина. 2021;24(12):97–104.
  7. Lazdam M., Davis E.F., Lewandowski A.J., Worton S.A., Kenworthy Y., Kelly B., Leeson P. Prevention of vascular dysfunction after preeclampsia: a potential long-term outcome measure and an emerging goal for treatment. J Pregnancy. 2012;2012:704146.
  8. Khong S.L., Kane S.C., Brennecke S.P., da Silva Costa F. First-trimester uterine artery Doppler analysis in the prediction of later pregnancy complications. Dis Markers. 2015;2015:679730.
  9. Magee L.A., von Dadelszen P., Singer J., Lee T., Rey E. Can adverse maternal and perinatal outcomes be predicted when blood pressure becomes elevated? Secondary analyses from the CHIPS randomized controlled trial. Acta Obstet Gynecol Scand. 2016;95(7):763–776.
  10. Tranquilli A.L., Dekker G., Magee L., Roberts J., Sibai B.M., Steyn W., Zeeman G.G., Brown M.A. The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP. Pregnancy Hypertens. 2014;4(2):97–104.
  11. Payne B., Hodgson S., Hutcheon J.A., Joseph K.S., Li J., Lee T., Magee L.A., Qu Z., von Dadelszen P.; PIERS Study Group. Performance of the full PIERS model in predicting adverse maternal outcomes in pre-eclampsia using patient data from the PIERS cohort. BJOG. 2013;120(1):113–118.

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