124 -2 (88) 2026 - Satvaldiyeva E.A., Durdiev N.Y. - POSTOPERATIVE ANALGESIA WITH NON-OPIOID ANALGESICS AND ITS IMPACT ON THE FREQUENCY OF EARLY COMPLICATIONS IN NEWBORNS: SINGLE-CENTER COMPARATIVE STUDY

POSTOPERATIVE ANALGESIA WITH NON-OPIOID ANALGESICS AND ITS IMPACT ON THE FREQUENCY OF EARLY COMPLICATIONS IN NEWBORNS: SINGLE-CENTER COMPARATIVE STUDY

Satvaldiyeva E.A. - National Children's Medical Center

Durdiev N.Y. - National Children's Medical Center

Resume

Opioids are traditionally used for the postoperative anesthesia of newborns and infants with congenital malformations of the abdominal organs and urinary system. However, they cause serious side effects such as excessive sedation, respiratory disorders (up to apnea), PODR, intestinal paresis, urinary retention, skin itching, slow down rehabilitation, and hinder the implementation of ERAS principles in neonatology. Currently, a multimodal approach based on non-opioid analgesics is recommended, however, the effectiveness of drugs such as paracetamol and ibuprofen in newborns has not been sufficiently studied. Therefore, this study is aimed at assessing the impact of non-opioid analgesia on clinical outcomes after TMS correction.

Key words: Postoperative analgesia, non-opioid analgesics, newborns, early postoperative complications.

First page

653

Last page

661

For citation:Satvaldiyeva E.A., Durdiev N.Y. - POSTOPERATIVE ANALGESIA WITH NON-OPIOID ANALGESICS AND ITS IMPACT ON THE FREQUENCY OF EARLY COMPLICATIONS IN NEWBORNS: SINGLE-CENTER COMPARATIVE STUDY//New Day in Medicine 2(88)2026 653-661 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

1. Gan TJ, Belani KG, Bergese S, Chung F, Diemunsch P, Habib AS, Jin Z, Kovac A, Meyer TA, Urman RD, Apfel CC. Fourth consensus guidelines for the manage- ment of postoperative nausea and vomiting. Anesth Analg. 2020;131(2):411–48. https://doi.org/10.1213/ANE.0000000000004833
2. Hertig JB, Louden L, Shay B, et al. Assessing the costs of intravenous push waste in intraoperative areas through observation: a multi-site study. Drugs Real World Outcomes. 2024;11(4):635–45. https://doi.org/10.1007/s40801-02 4-00456-9.
3. Holsti L, Grunau RE. Initial validation of the Behavioral Indicators of Infant Pain (BIIP). Pain 2007; 132:264.
4. Hummel P, Lawlor-Klean P, Weiss MG. Validity and reliability of the N-PASS assessment tool with acute pain. J Perinatol 2010; 30:474.
5. Kinoshita M, Borges do Nascimento IJ, Styrmisdóttir L, Bruschettini M. Systemic opioid regimens for postoperative pain in neonates. Cochrane Database Syst Rev 2023; 4:CD015016.6:1225
6. McNicol ED, Rowe E, Cooper TE. Ketorolac for postoperative pain in children. Cochrane Database Syst Rev 2018; 7:CD012294.
7. Ringsten M, Kredo T, Ebrahim S, et al. Diclofenac for acute postoperative pain in children. Cochrane Database Syst Rev 2023; 12:CD015087.
8. Roué JM, Rioualen S, Gendras J, et al. Multi-modal pain assessment: are near-infrared spectroscopy, skin conductance, salivary cortisol, physiologic parameters, and Neonatal Facial Coding System interrelated during venepuncture in healthy, term neonates? J Pain Res 2018; 11:2257.
9. Slater R, Cornelissen L, Fabrizi L, et al. Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial. Lancet 2010; 37
10. Stephan BC, Parsa FD. Avoiding Opioids and their harmful side effects in the postoperative patient: exogenous Opioids, endogenous Endorphins, wellness, mood, and their relation to postoperative pain. Hawaii J Med Public Health. 2016;75(3):63–67.
11. Yaster M. Multimodal analgesia in children. Eur J Anaesthesiol 2010; 27:851.
12. Zhu A, Benzon HA, Anderson TA. Evidence for the Efficacy of Systemic Opioid-Sparing Analgesics in Pediatric Surgical Populations: A Systematic Review. Anesth Analg 2017; 125:1569.

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