127 - 2 (88) 2026 - Yaxyoyeva X.Sh., Kayimova O.A. - DETECTION OF THYROID PATHOLOGY AND ANALYSIS OF CLINICAL AND LABORATORY INDICATORS IN PATIENTS WITH TYPE I DIABETES

DETECTION OF THYROID PATHOLOGY AND ANALYSIS OF CLINICAL AND LABORATORY INDICATORS IN PATIENTS WITH TYPE I DIABETES

Yaxyoyeva X.Sh. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Yaxyoyeva X.Sh. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Resume

This article examines the detection of thyroid gland pathology and the analysis of clinical and laboratory parameters in patients with type 1 diabetes mellitus. The study focuses on the assessment of thyroid function using thyroid-stimulating hormone, free thyroxine, and free triiodothyronine levels, as well as the diagnostic value of thyroid autoimmunity markers, including anti-thyroid peroxidase and anti-thyroglobulin antibodies. The results indicate that thyroid disorders in patients with type 1 diabetes mellitus often occur in a subclinical form and are closely associated with glycemic control parameters. A comprehensive evaluation of clinical and laboratory indicators contributes to early diagnosis, optimization of individualized management strategies, and reduction of long-term diabetes-related complications.

Keywords: type 1 diabetes mellitus, thyroid pathology, autoimmune thyroiditis, thyroid-stimulating hormone, free thyroxine, anti-TPO antibodies, anti-Tg antibodies, subclinical hypothyroidism, glycemic control, clinical and laboratory analysis.

First page

672

Last page

679

For citation:Yaxyoyeva X.Sh., Kayimova O.A. - DETECTION OF THYROID PATHOLOGY AND ANALYSIS OF CLINICAL AND LABORATORY INDICATORS IN PATIENTS WITH TYPE I DIABETES//New Day in Medicine 2(88)2026 672-679 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

1. International Diabetes Federation; T1D Index Group. Global type 1 diabetes prevalence, incidence, and mortality estimates 2025: Results from the International Diabetes Federation Atlas, 11th Edition, and the T1D Index Version 3.0. Diabetes Res Clin Pract. 2025;210:110703.
2. Alwan H, et al. Diabetes and thyroid diseases are closely associated endocrine disorders: A systematic review and meta-analysis (Type 1 diabetes and thyroid dysfunction focus). Endocrine. 2024;84(2):345–360.
3. American Diabetes Association. 14. Children and adolescents: Standards of care in diabetes—2025. Diabetes Care. 2025;48(Suppl 1):S283–S305. DOI: 10.2337/dc25-S014
4. Carreras G, et al. Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction: A thirty-years retrospective longitudinal study. Front Endocrinol (Lausanne). 2025;16:1298745.
5. Herczeg V, Muzslay E, Czipó D, Terkovics A, Takács A, Garai D, et al. Increasing prevalence of thyroid autoimmunity in childhood type 1 diabetes in the pre-COVID but not during the COVID era. Front Endocrinol (Lausanne). 2025;16:1289031.
6. Jonsdottir B, Clasen JL, Vehik K, Lernmark Å, Lundgren M, Bonifacio E, et al.; TEDDY Study Group. Early appearance of thyroid autoimmunity in children followed from birth for type 1 diabetes risk. J Clin Endocrinol Metab. 2025;110(2):498–507. DOI: 10.1210/clinem/dgad676
7. Skov J, et al. Shared etiology of type 1 diabetes and Hashimoto’s thyroiditis. Eur J Endocrinol. 2022;186(6):677–685. DOI: 10.1530/EJE-21-1163
8. Kordonouri O, Klinghammer A, Lang EB, Grüters-Kieslich A, Grabert M, Holl RW. Thyroid autoimmunity in children and adolescents with type 1 diabetes: A multicenter analysis. Pediatr Diabetes. 2023;24(5):678–686. DOI: 10.1111/pedi.13482
9. Triantafyllou GA, Paschou SA, Mantzou A, Vryonidou A, Papadakis GZ. Thyroid disease in patients with type 1 diabetes mellitus: A narrative review. Endocrine. 2022;77(2):220–230. DOI: 10.1007/s12020-022-03066-9
10. De Block CEM, De Leeuw IH, Van Gaal LF. Autoimmune thyroid disease in type 1 diabetes: A clinically oriented review. Eur J Endocrinol. 2023;188(4):R55–R68. DOI: 10.1530/EJE-22-0861
11. Lombardo F, Salzano G, Crisafulli G, et al. Subclinical hypothyroidism in children with type 1 diabetes: Impact on metabolic control. J Pediatr Endocrinol Metab. 2024;37(1):45–53. DOI: 10.1515/jpem-2023-0321

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