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  • 129 -2 (88) 2026 - Isaxanova N.X. - EVALUATION OF CLINICAL AND LABORATORY PARAMETERS IN ASSESSING THE ADAPTIVE STATUS OF CHILDREN WITH CONGENITAL HEART DEFECTS

129 -2 (88) 2026 - Isaxanova N.X. - EVALUATION OF CLINICAL AND LABORATORY PARAMETERS IN ASSESSING THE ADAPTIVE STATUS OF CHILDREN WITH CONGENITAL HEART DEFECTS

EVALUATION OF CLINICAL AND LABORATORY PARAMETERS IN ASSESSING THE ADAPTIVE STATUS OF CHILDREN WITH CONGENITAL HEART DEFECTS

Isaxanova N.X. - Tashkent State Medical University

Resume

This study is aimed at evaluating clinical and laboratory parameters in assessing the adaptive status of children with congenital heart defects (CHDs). A total of 294 children aged 1 to 7 years were examined and divided into two groups according to cyanotic and acyanotic forms of CHDs. Growth and development indicators, acid–base balance, electrolyte levels, and biochemical markers were assessed in the preoperative and postoperative periods. The results demonstrated that children with cyanotic CHDs exhibited more pronounced metabolic and molecular alterations associated with chronic hypoxia, including significantly elevated HIF-1α levels. In contrast, children with acyanotic CHDs showed milder and more rapidly compensated changes. The findings highlight the importance of early diagnosis, continuous monitoring, and individualized management strategies for improving outcomes in children with congenital heart defects.

Keywords: cyanotic congenital heart defects, acid–base parameters, biochemical markers.

First page

684

Last page

690

For citation:Isaxanova N.X. - EVALUATION OF CLINICAL AND LABORATORY PARAMETERS IN ASSESSING THE ADAPTIVE STATUS OF CHILDREN WITH CONGENITAL HEART DEFECTS //New Day in Medicine 2(88)2026 684-690 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

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