130 -2 (88) 2026 - Yuldasheva G.G., Bobokulova M.B. - THE PROGNOSTIC SIGNIFICANCE OF CYTOKINE STATUS IN EARLY INFLAMMATORY RESPONSE IN THE DEVELOPMENT OF BRONCHOPULMONARY DYSPLASIA IN EXTREMELY PREMATURE INFANTS

THE PROGNOSTIC SIGNIFICANCE OF CYTOKINE STATUS IN EARLY INFLAMMATORY RESPONSE IN THE DEVELOPMENT OF BRONCHOPULMONARY DYSPLASIA IN EXTREMELY PREMATURE INFANTS

Yuldasheva G.G. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Bobokulova M.B. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Resume

Bronchopulmonary dysplasia (BPD) is one of the most common and severe chronic lung diseases in premature infants with extremely low birth weight (≤1000 g). The pathogenesis of the disease is associated with impaired normal lung tissue development combined with inflammatory processes. In recent years, increasing attention has been paid to the study of cytokines as biomarkers of inflammation capable of predicting the development of BPD in the early stages of a child's life. This article systematises data on the role of key cytokines and their prognostic potential. It has been established that in extremely premature infants, IL1PA levels > 712 pg/ml and IL6 > 30 pg/ml predict the development of BPD.

Keywords: IL1PA, IL6, IL10, BPD, extremely low birth weight, premature infants.

First page

691

Last page

694

For citation:Yuldasheva G.G., Bobokulova M.B. - THE PROGNOSTIC SIGNIFICANCE OF CYTOKINE STATUS IN EARLY INFLAMMATORY RESPONSE IN THE DEVELOPMENT OF BRONCHOPULMONARY DYSPLASIA IN EXTREMELY PREMATURE INFANTS//New Day in Medicine 2(88)2026 691-694 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

1. Bakhmetyeva OB. Risk factors for the development of bronchopulmonary dysplasia in children with extremely low birth weight. Children’s Medicine of the North-West. 2025;77(56). DOI:10.56871/CmN-W.2025.77.56.013.
2. Davydova IV. Current possibilities for predicting the development of bronchopulmonary dysplasia in premature infants. Doctor.Ru. 2025;24(3):76–79.
3. Lebedeva OV. Morbidity and mortality of children with very low and extremely low birth weight: risk factors and ways to reduce them. Bulletin of New Medical Technologies. Electronic edition. 2015;9(2):30.
4. Lebedeva OV. Optimisation of diagnosis, prediction and prevention of perinatal complications in children with very low and extremely low birth weight [abstract of doctoral dissertation in medical sciences]. Astrakhan; 2015. 49 p.
5. Polyana EZ, Kuzmina ON, Trambitskaya EL. Features of the course of respiratory distress syndrome in premature infants with concomitant toxic-metabolic lesions of the central nervous system. In: Problems and prospects for the development of science in Russia and the world: collection of articles of the International Scientific and Practical Conference; 2016 Jun 5; Kirov. Ufa: Aeterna; 2016. Pt 2. p. 155–163.
6. Polyanina EZ, Lebedeva OV, Nevryuzina GO. The principle of habilitation in the system of medical and pedagogical correction of children born with very low and extremely low body weight. In: Andulyana IV, editor. Theoretical and practical aspects of psychology and pedagogy: collective monograph. Ufa: Aeterna; p. 124–138.
7. Polyanina EZ, Melyuchenkov MA, Uteshova IA. Red blood cell counts in children with very low and extremely low birth weight against the background of complex treatment of early anaemia in premature infants. In: Traditional and innovative science: history, current state, prospects: collection of articles of the International Scientific and Practical Conference; 2016 Jun 1; Ufa. Symbol of Science. 2017;01-2. Pt 3. p. 261–265.
8. Tsareva ZhA, Tsarkova SA, Leshchenko IV. Evolution of the assessment of cardiovascular consequences of bronchopulmonary dysplasia from childhood to adulthood. Russian Medical Journal (RMJ). 2025;(8).
9. Nikitina IV, Inviyaeva EV, et al. Plasma cytokine level changes in preterm neonates with respiratory disorders in the early neonatal period. Obstetrics and Gynaecology. 2021;(8):133–142.

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