135 -2 (88) 2026 - Urakov Sh.T., Rajabov M.M. - FIRST SUCCESSFUL LIVER TRANSPLANTATION IN BUKHARA REGION: CLINICAL EXPERIENCE AND SCIENTIFIC ANALYSIS

FIRST SUCCESSFUL LIVER TRANSPLANTATION IN BUKHARA REGION: CLINICAL EXPERIENCE AND SCIENTIFIC ANALYSIS

Urakov Sh.T. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Rajabov M.M. - Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Abdurakhmanov Sh.M. - Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Abidov U.O. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Khamroev B.S. - Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Komilov Zh.D. - Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Dehqonov M.A. - Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Kholikov F.Y. - Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Resume

This article presents a clinical case of liver transplantation performed in a patient with end-stage liver cirrhosis. Patient N.V. (born in 1981) had clinically and laboratory confirmed terminal liver cirrhosis manifested by severe liver failure, portal hypertension, and related complications. According to MELD and Child–Pugh scoring systems, the patient was classified as high-risk. Due to the failure of conservative treatment, liver transplantation was considered the optimal therapeutic approach. A close relative (the patient’s spouse) was selected as a living donor, and immunological as well as anatomical compatibility was thoroughly assessed. The surgical procedure was carried out by a highly qualified multidisciplinary team in accordance with international protocols, including donor graft preparation, hepatectomy, vascular anastomosis, and biliary reconstruction. Postoperatively, the patient was monitored in the intensive care unit and received standard immunosuppressive therapy. Short-term follow-up results demonstrated stable graft function and significant clinical improvement. This clinical case supports liver transplantation as an effective treatment option for patients with end-stage liver cirrhosis.

Keywords: liver transplantation, liver cirrhosis, MELD, Child–Pugh, portal hypertension, immunosuppression.

First page

720

Last page

725

For citation:Urakov Sh.T., Rajabov M.M., Abdurakhmanov Sh.M., Abidov U.O., Khamroev B.S., Komilov Zh.D., Dehqonov M.A., Kholikov F.Y. - FIRST SUCCESSFUL LIVER TRANSPLANTATION IN BUKHARA REGION: CLINICAL EXPERIENCE AND SCIENTIFIC ANALYSIS//New Day in Medicine 2(88)2026 720-725 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

List of References

1. Сафаров Б.Ш., Охунов А.О., Саидов М.А. Жигар касалликларида замонавий жарроҳлик усуллари. Тошкент: Ибн Сино номидаги тиббиёт нашриёти; 2018.
2. Абдуллаев А.А., Каримов Ш.И. Жигар циррозини комплекс даволашнинг клиник жиҳатлари. Ўзбекистон тиббиёт журнали. 2019;(4):45–50.
3. Рахмонов Н.Х., Исмоилов Ф.Р. Терминал жигар етишмовчилигида юқори технологияли тиббий ёрдам. Клиник ва экспериментал тиббиёт. 2020;(2):33–38.
4. Турсунов Д.К., Норматов Н.Н. Ўзбекистонда трансплантология хизмати ривожланишининг ҳозирги ҳолати. Соғлиқни сақлаш ахборотномаси. 2021;(1):12–18.
5. Мухаммадиев Р.Р., Холмуродов Ш.А. Иммуносупрессив терапиянинг клиник самарадорлиги. Фармакология ва токсикология. 2021;(5):58–63.
6. Готье С.В. Трансплантация печени в Российской Федерации: состояние и перспективы. Вестник трансплантологии и искусственных органов. 2019;21(1):10–19.
7. Мойсюк Я.Г., Готье С.В. Живое родственное донорство печени. Анналы хирургической гепатологии. 2018;23(1):7–16.
8. Попцов В.Н., Шевченко О.П. Иммуносупрессия после трансплантации печени. Клиническая фармакология и терапия. 2017;26(3):45–52.

   file

   download