137 -2 (88) 2026 - Adizov S.R., Abdullaeva M.A. - MORPHOLOGICAL AND MORPHOMETRIC CHANGES IN THE PANCREAS OF WHITE MISTREATENED RATS OF DIFFERENT AGES EXPOSED TO CARBON MONOXIDE (CO₂)

MORPHOLOGICAL AND MORPHOMETRIC CHANGES IN THE PANCREAS OF WHITE MISTREATENED RATS OF DIFFERENT AGES EXPOSED TO CARBON MONOXIDE (CO₂)

Adizov S.R. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Abdullaeva M.A. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Resume

This study investigates morphological and morphometric alterations in the pancreatic tissues of white outbred rats of different ages (3 and 12 months) subjected to chronic carbon monoxide (СО₂) exposure. Histological evaluation was performed using hematoxylin and eosin staining. The results demonstrated that long-term low-dose exposure to carbon monoxide induces significant structural damage in both the exocrine and endocrine components of the pancreas. In 3-month-old rats, acinar cell vacuolization, a reduction in secretory granules, decreased nuclear diameter, β-cell dystrophy in the islets of Langerhans, and microcirculatory disturbances were observed. In 12-month-old rats, these pathological changes were more severe and irreversible, characterized by acinar atrophy, endocrine tissue destruction, fibrosis, and microangiopathy. Morphometric analysis confirmed an age-dependent intensification of the toxic-hypoxic effects of carbon monoxide and a pronounced disruption of pancreatic structural and functional integrity. These findings provide valuable insight into the pathogenesis of pancreatic damage under chronic carbon monoxide intoxication and may serve as a scientific basis for preventive and therapeutic strategies.

Key words: carbon monoxide, pancreas, acinar dystrophy, islets of Langerhans, hypoxia, morphometry, microangiopathy.

First page

729

Last page

733

For citation:Adizov S.R., Abdullaeva M.A. - MORPHOLOGICAL AND MORPHOMETRIC CHANGES IN THE PANCREAS OF WHITE MISTREATENED RATS OF DIFFERENT AGES EXPOSED TO CARBON MONOXIDE (CO₂)//New Day in Medicine 2(88)2026 729-733 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

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