159 -2 (88) 2026 - Obidov F.Kh., Mavlyanova Z.F. - AN INTEGRATED APPROACH TO THE DIAGNOSIS AND TREATMENT OF STAGE I–II CHRONIC CEREBRAL ISCHEMIA

AN INTEGRATED APPROACH TO THE DIAGNOSIS AND TREATMENT OF STAGE I–II CHRONIC CEREBRAL ISCHEMIA

Obidov F.Kh. - Samarkand State Medical University

Mavlyanova Z.F. - Samarkand State Medical University

Djurabekova A.T. - Samarkand State Medical University

Ashurov R.F. - Samarkand State Medical University

Resume

The article presents the results of evaluating the applied diagnostic and rehabilitation algorithm in patients with stage I–II chronic cerebral ischemia. The study included clinical, laboratory, and instrumental assessments using neuroimaging techniques. The implementation of the developed algorithm was associated with a significant reduction in the severity of dizziness, fatigue, and sleep disturbances, a decrease in the levels of pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor-alpha), and an increase in brain-derived neurotrophic factor levels. Magnetic resonance imaging revealed improved cerebral perfusion, positive changes in the microstructure of white matter, and a reduction in the manifestations of microangiopathy. The obtained results confirm the advantages of the comprehensive approach over standard therapy and support its implementation in clinical practice to slow disease progression and improve patients’ quality of life.

Keywords: chronic cerebral ischemia; neuroinflammation; neuroplasticity; interleukin-6; tumor necrosis factor-alpha; brain-derived neurotrophic factor; magnetic resonance imaging; cerebral perfusion; microangiopathy; rehabilitation.

First page

854

Last page

860

For citation:Obidov F.Kh., Mavlyanova Z.F., Djurabekova A.T., Ashurov R.F. - AN INTEGRATED APPROACH TO THE DIAGNOSIS AND TREATMENT OF STAGE I–II CHRONIC CEREBRAL ISCHEMIA//New Day in Medicine 2(88)2026 854-860 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

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