168 -2 (88) 2026 - Dehqonov Q.A., Beknazarov J.B. - MORPHOFUNCTIONAL DISORDERS OF CELL MEMBRANES IN UROLITHIASIS COMPLICATED BY OBSTRUCTIVE PYELONEPHRITIS BEFORE AND AFTER

MORPHOFUNCTIONAL DISORDERS OF CELL MEMBRANES IN UROLITHIASIS COMPLICATED BY OBSTRUCTIVE PYELONEPHRITIS BEFORE AND AFTER INACTIVE CORRECTION

Dehqonov Q.A. - Tashkent Medical University

Beknazarov J.B. - Tashkent Medical University

Beknazarov Z.J. - Tashkent Medical University

Yusufjonov A.B. - Tashkent Medical University

Umanest R.V. - Tashkent Medical University

Abdurahmonov B. - Tashkent Medical University

Shagiyazova L.M. - Tashkent Medical University

Resume

The problem of urolithiasis and urinary tract infection in childhood, especially in hot climate regions, continues to be the focus of pediatric urology. Purpose of the research: To study morphofunctional disorders of cell membranes in urolithiasis complicated by obstructive pyelonephritis, and complex correction of the metabolic process in the experiment. Material and methods: Experimental studies were carried out on 65 (5-6 months old) male rabbits of the "chinchilla" breed, weighing 3000-3500 g. All animals were divided into 2 groups: group 1, EOP, against the background of traditional treatment - 30 rabbits; Group 2, EOP, against the background of metabolic treatment - 35 rabbits. Results and discussion: In experimental animals, on day 15 without treatment, glomeruli plethora is observed, the epithelium of the proximal and distal tubules is flattened, and the brush border is reduced in places. In 3 months after metabolic therapy in animals, the structure is mosaic, along with destructively altered areas, they are revealed with a normal structure. In 6 months after the start of metabolic treatment, the main part of the renal tissue has a normal structure, areas with destructively altered nephron tubules are relatively less often visible, and sclerosis is almost not detected. Video information is provided on case studies of puncture laser lithotripsy for kidney stones followed by metabolic correction of the patient's condition. This technique resulted in a shorter postoperative hospital stay. On experimental models with obstructive pyelonephritis, in order to develop a complex method of metabolic therapy in the dynamics of the disease, we conducted morphological and clinical-biochemical studies in 4 groups of animals: 1 - intact, 2 - untreated, 3 - traditional treatment and 4 - metabolic treatment.

Key words: morphofunctional disorders of cell membranes in urolithiasis, complicated obstructive pyelonephritis, experimental studies

First page

907

Last page

916

For citation:Dehqonov Q.A., Beknazarov J.B., Beknazarov Z.J., Yusufjonov A.B., Umanest R.V., Abdurahmonov B., Shagiyazova L.M. - MORPHOFUNCTIONAL DISORDERS OF CELL MEMBRANES IN UROLITHIASIS COMPLICATED BY OBSTRUCTIVE PYELONEPHRITIS BEFORE AND AFTER INACTIVE CORRECTION//New Day in Medicine 2(88)2026 907-916 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

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