171 -2 (88) 2026 - Djumayeva Sh.D. - CONGENITAL DISORDERS OF IMMUNITY WITH SUSCEPTIBILITY TO STAPHYLOCOCCUS AUREUS INFECTIONS: CLINICAL AND IMMUNOLOGICAL REVIEW

CONGENITAL DISORDERS OF IMMUNITY WITH SUSCEPTIBILITY TO STAPHYLOCOCCUS AUREUS INFECTIONS: CLINICAL AND IMMUNOLOGICAL REVIEW

Djumayeva Sh.D. - Bukhara State Medical Institute named after Abu Ali ibn Sinа

Resume

This review analyzes congenital disorders of immunity associated with increased susceptibility to Staphylococcus aureus infections based on current international and domestic literature. These conditions are characterized by marked clinical heterogeneity, variable age of onset, and frequent diagnostic delay. Particular attention is paid to defects of innate immunity, neutrophil dysfunction, IL-17 and IFN-γ signaling pathway abnormalities, and syndromic forms with predominant skin and soft tissue involvement. S. aureus infections often represent the leading clinical manifestation prompting suspicion of an inborn error of immunity. The review highlights the importance of early recognition and standardized diagnostic approaches.

Keywords: inborn errors of immunity, Staphylococcus aureus, recurrent infections, innate immunity, neutrophil dysfunction, early diagnosis.

First page

930

Last page

933

For citation:Djumayeva Sh.D. - CONGENITAL DISORDERS OF IMMUNITY WITH SUSCEPTIBILITY TO STAPHYLOCOCCUS AUREUS INFECTIONS: CLINICAL AND IMMUNOLOGICAL REVIEW//New Day in Medicine 2(88)2026 930-933 https://newdayworldmedicine.com/en/new_day_medicine/2-88-2026

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