17 -3 (89) 2026 - D.Sh. Polatova, A.Yu. Madaminov - COMBINATION OF CELLULAR PHENOTYPING WITH CHROMOSOMAL SIGNALS IN HEMATO-ONCOLOGICAL DISEASES

COMBINATION OF CELLULAR PHENOTYPING WITH CHROMOSOMAL SIGNALS IN HEMATO-ONCOLOGICAL DISEASES

D.Sh. Polatova - Scientific and Practical Medical Center for Children's Oncology, Hematology and Immunology, Republic of Uzbekistan, Tashkent State Medical University

A.Yu. Madaminov - Scientific and Practical Medical Center for Children's Oncology, Hematology and Immunology, Republic of Uzbekistan, Tashkent State Medical University

Kh.I. Jumaniyozov - Scientific and Practical Medical Center for Children's Oncology, Hematology and Immunology, Republic of Uzbekistan, Tashkent State Medical University

M.N. Tashmetov - Scientific and Practical Medical Center for Children's Oncology, Hematology and Immunology, Republic of Uzbekistan, Tashkent State Medical University

Resume

When diagnosing hemato-oncological diseases (HOD), timely identification of phenotypic and genetic markers in tumor cells is of great importance for adequate prognostic assessment and selection of an effective treatment option. The multiparameter Immuno-flowFISH method, integrating immunophenotyping, flow cytometry and FISH, allows the simultaneous detection of multiple molecular markers in the membrane and chromosome of tumor cells. Currently, a large number of chromosomal aberrations that occur with varying frequencies and are associated with a certain variant of HOD have been identified. One of the main advantages of the Immuno-flowFISH method is the qualitative and quantitative morphophenotypic identification of single cells based on chromosomal FISH signals using various analytical tools in an automated manner. It is not surprising that in the near future, the use of the full technological potential of the Immuno-flowFISH method will open many constructive horizons in the study and treatment of hemato-oncological diseases.

Key words: hemato-oncological diseases, flow cytometry, immunophenotyping, FISH, Immuno-flowFISH.

First page

96

Last page

102

For citation:D.Sh. Polatova, A.Yu. Madaminov, Kh.I. Jumaniyozov, M.N. Tashmetov - COMBINATION OF CELLULAR PHENOTYPING WITH CHROMOSOMAL SIGNALS IN HEMATO-ONCOLOGICAL DISEASES//New Day in Medicine 3(89)2026 96-102 https://newdayworldmedicine.com/en/new_day_medicine/3-89-2026

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