24 -3 (89) 2026 - Shermatov A.A., Mirzayev K.K. - MORPHOLOGICAL FEATURES OF WOUND HEALING IN EXPERIMENTAL ANIMALS WITH DIABETES MELLITUS UNDER VARIOUS METHODS OF HEMOSTASIS"

MORPHOLOGICAL FEATURES OF WOUND HEALING IN EXPERIMENTAL ANIMALS WITH DIABETES MELLITUS UNDER VARIOUS METHODS OF HEMOSTASIS"

Shermatov A.A. - Andijan State Medical Institute

Mirzayev K.K. - State Institution "Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov"

Sodiqov R.A. - State Institution "Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov"

Resume

Morphological studies of the healing processes in stump tissues after limb amputation against the background of experimental diabetes mellitus were conducted. It has been noted that the course of the wound healing process and the severity of the inflammatory response in the early stages after surgery are determined by the peculiarities of primary hemostasis. In the control group, more pronounced microcirculatory disorders, prolonged persistence of inflammatory infiltration, and delayed formation of granulation tissue were observed, accompanied by late maturation of connective tissue. The use of the developed plastic local hemostatic agent in the experimental group ensured early stabilization of hemostasis and a faster reduction of the inflammatory response. This contributed to the early activation of angiogenesis and accelerated formation of granulation tissue with a homogeneous scar. The identified morphological features showed that the use of the developed plastic local hemostatic agent creates more favorable conditions for healing in stump tissues and justifies a decrease in the frequency of inflammatory complications, thereby reducing healing time.

Keywords: experimental diabetes mellitus, hemostasis, wound pathomorphology.

First page

135

Last page

145

For citation:Shermatov A.A., Mirzayev K.K., Sodiqov R.A. - MORPHOLOGICAL FEATURES OF WOUND HEALING IN EXPERIMENTAL ANIMALS WITH DIABETES MELLITUS UNDER VARIOUS METHODS OF HEMOSTASIS"//New Day in Medicine 3(89)2026 135-145 https://newdayworldmedicine.com/en/new_day_medicine/3-89-2026

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