35 -3 (89) 2026 - Narzikulov U.Z., Jurayev I.G. - CHARACTERISTICS OF MORPHOLOGICAL CHANGES IN THE MYOCARDIUM IN THOSE WHO DIED FROM ISCHEMIC HEART DISEASE IN THE WINTER SEASON

CHARACTERISTICS OF MORPHOLOGICAL CHANGES IN THE MYOCARDIUM IN THOSE WHO DIED FROM ISCHEMIC HEART DISEASE IN THE WINTER SEASON

Narzikulov U.Z. - Samarkand State Medical University

Jurayev I.G. - Samarkand State Medical University

Resume

This article is devoted to the study of the features of morphological changes in the myocardium of 42 people who died in winter due to coronary heart disease. Based on the materials of the forensic medical examination, a comparative analysis of the macroscopic and microscopic parameters of the heart was conducted. Macroscopic examination revealed an increase in heart mass, thickening of the left ventricle wall, dilation of chambers, clouding of myocardial consistency, and an increase in interstitial edema elements. Histological analysis revealed signs of cardiomyocyte fiber disorganization, hypertrophy and hyperchromia of the nuclei, increased intermuscular spacing, perivascular hyperemia, and interstitial edema. In some cases, elements of fibrosis and segmental dystrophic changes were observed. The obtained results indicate an intensification of ischemic-dystrophic processes against the background of peripheral vasoconstriction and increased hemodynamic load during the winter period.

Keywords: ischemic heart disease, winter season, myocardial morphology, sudden death, forensic medical examination, cardiomyocyte hypertrophy, interstitial edema, perivascular congestion, fibrosis.

First page

215

Last page

220

For citation:Narzikulov U.Z., Jurayev I.G. - CHARACTERISTICS OF MORPHOLOGICAL CHANGES IN THE MYOCARDIUM IN THOSE WHO DIED FROM ISCHEMIC HEART DISEASE IN THE WINTER SEASON//New Day in Medicine 3(89)2026 215-220 https://newdayworldmedicine.com/en/new_day_medicine/3-89-2026

List of References

1. Heusch G. Myocardial ischemia: lack of coronary blood flow and reperfusion injury. Eur Heart J. 2020;41(19):1804-1812. doi:10.1093/eurheartj/ehz872.
2. Chen Q, Lesnefsky EJ. Mitochondrial dysfunction and myocardial ischemia–reperfusion injury. Am J Physiol Heart Circ Physiol. 2020;318(3):H606-H616. doi:10.1152/ajpheart.00654.2019.
3. Chouchani ET, Pell VR, Gaude E, et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 2021;515(7527):431-435. doi:10.1038/nature13909.
4. Turer AT, Hill JA. Pathogenesis of myocardial ischemia–reperfusion injury and rationale for therapy. Am J Cardiol. 2021;128:30-36. doi:10.1016/j.amjcard.2020.10.022.
5. Zhang Y, Wang J, Li Q, et al. Sarcomere disorganization and contractile dysfunction in ischemic myocardium. J Mol Cell Cardiol. 2022;162:25-34. doi:10.1016/j.yjmcc.2021.11.003.
6. Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the NCCD 2020. Cell Death Differ. 2020;27(1):19-51. doi:10.1038/s41418-019-0486-2.
7. Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN. Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol Rev. 2022;102(4):1765-1817. doi:10.1152/physrev.00022.2021.
8. Coronel R, Wilms-Schopman FJG, Janse MJ. Early ischemic arrhythmias and cellular uncoupling. Heart Rhythm. 2021;18(2):251-258. doi:10.1016/j.hrthm.2020.09.028.
9. Basso C, Aguilera B, Banner J, et al. Guidelines for autopsy investigation of sudden cardiac death: 2022 update. Virchows Arch. 2022;480(1):1-28. doi:10.1007/s00428-021-03147-0.
10. Burke AP, Farb A, Malcom GT, et al. Sudden cardiac death: contemporary pathological concepts. Cardiovasc Pathol. 2023;62:107434. doi:10.1016/j.carpath.2022.107434.

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